Literature DB >> 26169400

Sulfamethoxazole susceptibility of Mycobacterium tuberculosis isolates from HIV-infected Ugandan adults with tuberculosis taking trimethoprim-sulfamethoxazole prophylaxis.

Sam Ogwang1, Caryn E Good2, Brenda Okware3, Mary Nsereko3, Michael R Jacobs2, W Henry Boom4, Charles M Bark5.   

Abstract

Additional drugs are needed for the treatment of multidrug-resistant tuberculosis (TB). Sulfamethoxazole has been shown to have in vitro activity against Mycobacterium tuberculosis; however, there is concern about resistance given the widespread use of trimethoprim-sulfamethoxazole prophylaxis among HIV-infected patients in sub-Saharan Africa. Thirty-eight of 40 Mycobacterium tuberculosis isolates (95%) from pretreatment sputum samples from Ugandan adults with pulmonary TB, including HIV-infected patients taking trimethoprim-sulfamethoxazole prophylaxis, were susceptible with MICs of ≤38.4 μg/ml.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID: 26169400      PMCID: PMC4538550          DOI: 10.1128/AAC.01101-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  13 in total

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3.  Cotrimoxazole prophylaxis decreases tuberculosis risk among Asian patients with HIV.

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