| Literature DB >> 26169400 |
Sam Ogwang1, Caryn E Good2, Brenda Okware3, Mary Nsereko3, Michael R Jacobs2, W Henry Boom4, Charles M Bark5.
Abstract
Additional drugs are needed for the treatment of multidrug-resistant tuberculosis (TB). Sulfamethoxazole has been shown to have in vitro activity against Mycobacterium tuberculosis; however, there is concern about resistance given the widespread use of trimethoprim-sulfamethoxazole prophylaxis among HIV-infected patients in sub-Saharan Africa. Thirty-eight of 40 Mycobacterium tuberculosis isolates (95%) from pretreatment sputum samples from Ugandan adults with pulmonary TB, including HIV-infected patients taking trimethoprim-sulfamethoxazole prophylaxis, were susceptible with MICs of ≤38.4 μg/ml.Entities:
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Year: 2015 PMID: 26169400 PMCID: PMC4538550 DOI: 10.1128/AAC.01101-15
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191