G A S Dias1, G T Yoshikawa2, R V L Koyama3, S Fujihara3, L C S Martins4, R Medeiros1, J A S Quaresma3, H T Fuzii1. 1. Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém, Brazil. 2. Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Brazil. 3. Centro de Ciências Biológicas e da Saúde, Universidade do Estado do Pará, Belém, Brazil. 4. Centro de Ciências Biológicas e da Saúde, Universidade da Amazônia, Belém, Brazil.
Abstract
STUDY DESIGN: A cross-sectional observational study was conducted. OBJECTIVE: The aim was to analyze the clinical-functional profile of patients diagnosed with HTLV-1 (human T-lymphotropic virus type 1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in the Amazon region. SETTING: Reference center for HTLV in the city of Belém, state of Pará, Brazil. METHODS: Muscle strength, muscle tone, balance and the need for gait assistance among patients with HAM/TSP were evaluated. RESULTS: Among the 82 patients infected with HTLV-1, 27 (10 men and 17 women) were diagnosed with HAM/TSP. No statistically significant difference in muscle tone or strength was found between the lower limbs. Muscle weakness and spasticity were predominant in the proximal lower limbs. Patients with HAM/TSP are at a high risk of falls (P=0.03), and predominantly use either a cane or a crutch on one side as a gait-assistance device (P=0.02). CONCLUSION: Patients with HAM/TSP exhibit a similar clinical pattern of muscle weakness and spasticity, with a high risk of falls, requiring gait-assistance devices.
STUDY DESIGN: A cross-sectional observational study was conducted. OBJECTIVE: The aim was to analyze the clinical-functional profile of patients diagnosed with HTLV-1 (human T-lymphotropic virus type 1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in the Amazon region. SETTING: Reference center for HTLV in the city of Belém, state of Pará, Brazil. METHODS: Muscle strength, muscle tone, balance and the need for gait assistance among patients with HAM/TSP were evaluated. RESULTS: Among the 82 patients infected with HTLV-1, 27 (10 men and 17 women) were diagnosed with HAM/TSP. No statistically significant difference in muscle tone or strength was found between the lower limbs. Muscle weakness and spasticity were predominant in the proximal lower limbs. Patients with HAM/TSP are at a high risk of falls (P=0.03), and predominantly use either a cane or a crutch on one side as a gait-assistance device (P=0.02). CONCLUSION:Patients with HAM/TSP exhibit a similar clinical pattern of muscle weakness and spasticity, with a high risk of falls, requiring gait-assistance devices.
Authors: Carlos M De Castro-Costa; Abelardo Q C Araújo; Márcio M Barreto; Osvaldo M Takayanagui; Marzia P Sohler; Eduardo L M da Silva; Sônia M B de Paula; Ricardo Ishak; João G R Ribas; Luis C Rovirosa; Herwig Carton; Eduardo Gotuzzo; William W Hall; Silvia Montano; Edward L Murphy; Joel Oger; Carlos Remondegui; Graham P Taylor Journal: AIDS Res Hum Retroviruses Date: 2006-10 Impact factor: 2.205
Authors: Luiz Cláudio Ferreira Romanelli; Paulo Caramelli; Anna Barbara de Freitas Carneiro Proietti Journal: Rev Assoc Med Bras (1992) Date: 2010 May-Jun Impact factor: 1.209
Authors: L D Facchinetti; A Q Araújo; G L Chequer; M F de Azevedo; R V C de Oliveira; M A Lima Journal: Spinal Cord Date: 2012-11-20 Impact factor: 2.772
Authors: Denise U Goncalves; Fernando A Proietti; Edel F Barbosa-Stancioli; Marina L Martins; João G Ribas; Olindo A Martins-Filho; Andrea Teixeira-Carvalho; Vanessa Peruhype-Magalhães; Anna B Carneiro-Proietti Journal: Inflamm Allergy Drug Targets Date: 2008-06
Authors: P A Montanheiro; A C Penalva de Oliveira; J Smid; L M I Fukumori; I Olah; A J da S Duarte; J Casseb Journal: Scand J Immunol Date: 2009-10 Impact factor: 3.487
Authors: Erika Pedreira da Fonseca; Katia Nunes Sá; Rebeca Freitas Reis Nunes; Camille Rosa de Jesus Souza; Mayra Castro de Matos Sousa; Elen Beatriz Pinto Journal: Rev Soc Bras Med Trop Date: 2021-01-29 Impact factor: 1.581
Authors: Flávia Dos Santos Souza; Nicole Lardini Freitas; Yago Côrtes Pinheiro Gomes; Rafael Carvalho Torres; Juliana Echevarria-Lima; Isaac Lima da Silva-Filho; Ana Claudia Celestino Bezerra Leite; Marco Antonio Sales Dantas de Lima; Marcus Tulius Teixeira da Silva; Abelardo de Queiroz Campos Araújo; Otávio Melo Espíndola Journal: Front Immunol Date: 2021-10-26 Impact factor: 7.561
Authors: Beatriz Helena B Vasconcelos; Givago S Souza; Tatiana G C P Barroso; Luiz Carlos L Silveira; Rita Catarina M Sousa; Bianca Callegari; Marília B Xavier Journal: PLoS One Date: 2016-03-21 Impact factor: 3.240