Ambarina S Faiz1, Imran Khan2, Michele G Beckman3, Paula Bockenstedt4, John A Heit5, Roshni Kulkarni6, Marilyn Manco-Johnson7, Stephan Moll8, Thomas L Ortel9, Claire S Philipp2. 1. Division of Hematology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA. Electronic address: faizas@rutgers.edu. 2. Division of Hematology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA. 3. Centers for Disease Control and Prevention, Atlanta, GA, USA. 4. Division of Hematology-Oncology, University of Michigan, Ann Arbor, MI, USA. 5. Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA. 6. Division of Pediatrics, Michigan State University, East Lansing, MI, USA. 7. University of Colorado and Children's Hospital, Aurora, CO, USA. 8. University of North Carolina, Chapel Hill, NC, USA. 9. Division of Hematology, Duke University Medical Center, Durham, NC, USA.
Abstract
INTRODUCTION: The objective of this study was to examine the differences in commonly associated characteristics and risk factors of venous thromboembolism (VTE) between patients with and without cancer in a VTE population. MATERIALS AND METHODS: Uniform data were collected for patients with a diagnosis of VTE obtaining care at CDC funded Thrombosis Network Centers. Patient characteristics and risk factors were compared in VTE patients with and without cancer. Logistic regression was used to calculate the unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) to assess patient characteristics and thrombotic risk factors more frequently identified among VTE patients with cancer compared to those without cancer. RESULTS: Between August 2003 and April 2011, 3,115 adult patients with a diagnosis of VTE including 189 (6.1%) patients with active cancer participated in the multi-site thrombosis registry. VTE patients with cancer had a higher prevalence of PE and DVT in unusual sites compared to those without cancer. Thrombophilia was more common among VTE patients without cancer than those with cancer (25.1% vs 10.6%, p<0.001). In adjusted analysis, age group≥45years (OR =5.20, 95% CI, 3.30, 8.18), surgery (OR =1.86, 95% CI, 1.19, 2.91), and hypertension (OR =1.66, 95% CI, 1.15, 2.40) were the VTE risk factors more commonly found among VTE patients with cancer. CONCLUSION: The study identified several thrombotic risk factors more likely to be found with cancer associated VTE, which may help to characterize at risk cancer patients and to develop prevention and management strategies in this population.
INTRODUCTION: The objective of this study was to examine the differences in commonly associated characteristics and risk factors of venous thromboembolism (VTE) between patients with and without cancer in a VTE population. MATERIALS AND METHODS: Uniform data were collected for patients with a diagnosis of VTE obtaining care at CDC funded Thrombosis Network Centers. Patient characteristics and risk factors were compared in VTEpatients with and without cancer. Logistic regression was used to calculate the unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) to assess patient characteristics and thrombotic risk factors more frequently identified among VTEpatients with cancer compared to those without cancer. RESULTS: Between August 2003 and April 2011, 3,115 adult patients with a diagnosis of VTE including 189 (6.1%) patients with active cancer participated in the multi-site thrombosis registry. VTEpatients with cancer had a higher prevalence of PE and DVT in unusual sites compared to those without cancer. Thrombophilia was more common among VTEpatients without cancer than those with cancer (25.1% vs 10.6%, p<0.001). In adjusted analysis, age group≥45years (OR =5.20, 95% CI, 3.30, 8.18), surgery (OR =1.86, 95% CI, 1.19, 2.91), and hypertension (OR =1.66, 95% CI, 1.15, 2.40) were the VTE risk factors more commonly found among VTEpatients with cancer. CONCLUSION: The study identified several thrombotic risk factors more likely to be found with cancer associated VTE, which may help to characterize at risk cancerpatients and to develop prevention and management strategies in this population.
Authors: John A Heit; W Michael O'Fallon; Tanya M Petterson; Christine M Lohse; Marc D Silverstein; David N Mohr; L Joseph Melton Journal: Arch Intern Med Date: 2002-06-10
Authors: Mary Cushman; Albert W Tsai; Richard H White; Susan R Heckbert; Wayne D Rosamond; Paul Enright; Aaron R Folsom Journal: Am J Med Date: 2004-07-01 Impact factor: 4.965