Literature DB >> 26167871

Epigenetics: Disrupting histone lysine methylation.

Patrick Trojer1.   

Abstract

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 26167871     DOI： 10.1038/nchembio.1861

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


× No keyword cloud information.
  9 in total

1.  Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.

Authors:  Venkatasubramanian Dharmarajan; Jeong-Heon Lee; Anamika Patel; David G Skalnik; Michael S Cosgrove
Journal:  J Biol Chem       Date:  2012-06-03       Impact factor: 5.157

2.  Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia.

Authors:  Fang Cao; Elizabeth C Townsend; Hacer Karatas; Jing Xu; Li Li; Shirley Lee; Liu Liu; Yong Chen; Peter Ouillette; Jidong Zhu; Jay L Hess; Peter Atadja; Ming Lei; Zhaohui S Qin; Sami Malek; Shaomeng Wang; Yali Dou
Journal:  Mol Cell       Date:  2014-01-02       Impact factor: 17.970

Review 3.  Targeting histone lysine methylation in cancer.

Authors:  John McGrath; Patrick Trojer
Journal:  Pharmacol Ther       Date:  2015-01-09       Impact factor: 12.310

4.  Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC.

Authors:  Lance R Thomas; Qingguo Wang; Brian C Grieb; Jason Phan; Audra M Foshage; Qi Sun; Edward T Olejniczak; Travis Clark; Soumyadeep Dey; Shelly Lorey; Bethany Alicie; Gregory C Howard; Bryan Cawthon; Kevin C Ess; Christine M Eischen; Zhongming Zhao; Stephen W Fesik; William P Tansey
Journal:  Mol Cell       Date:  2015-03-26       Impact factor: 17.970

5.  Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction.

Authors:  Yuri Bolshan; Matthäus Getlik; Ekaterina Kuznetsova; Gregory A Wasney; Taraneh Hajian; Gennadiy Poda; Kong T Nguyen; Hong Wu; Ludmila Dombrovski; Aiping Dong; Guillermo Senisterra; Matthieu Schapira; Cheryl H Arrowsmith; Peter J Brown; Rima Al-Awar; Masoud Vedadi; David Smil
Journal:  ACS Med Chem Lett       Date:  2013-02-04       Impact factor: 4.345

6.  The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.

Authors:  Pamela Zhang; Hwabin Lee; Joseph S Brunzelle; Jean-Francois Couture
Journal:  Nucleic Acids Res       Date:  2012-01-20       Impact factor: 16.971

7.  Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.

Authors:  Florian Grebien; Masoud Vedadi; Matthäus Getlik; Cheryl H Arrowsmith; Giulio Superti-Furga; Roberto Giambruno; Amit Grover; Roberto Avellino; Anna Skucha; Sarah Vittori; Ekaterina Kuznetsova; David Smil; Dalia Barsyte-Lovejoy; Fengling Li; Gennadiy Poda; Matthieu Schapira; Hong Wu; Aiping Dong; Guillermo Senisterra; Alexey Stukalov; Kilian V M Huber; Andreas Schönegger; Richard Marcellus; Martin Bilban; Christoph Bock; Peter J Brown; Johannes Zuber; Keiryn L Bennett; Rima Al-Awar; Ruud Delwel; Claus Nerlov
Journal:  Nat Chem Biol       Date:  2015-07-13       Impact factor: 15.040

8.  Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex.

Authors:  Jorge Dias; Nhuong Van Nguyen; Plamen Georgiev; Aline Gaub; Janine Brettschneider; Stephen Cusack; Jan Kadlec; Asifa Akhtar
Journal:  Genes Dev       Date:  2014-05-01       Impact factor: 11.361

9.  Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.

Authors:  Guillermo Senisterra; Hong Wu; Abdellah Allali-Hassani; Gregory A Wasney; Dalia Barsyte-Lovejoy; Ludmila Dombrovski; Aiping Dong; Kong T Nguyen; David Smil; Yuri Bolshan; Taraneh Hajian; Hao He; Alma Seitova; Irene Chau; Fengling Li; Gennadiy Poda; Jean-François Couture; Peter J Brown; Rima Al-Awar; Matthieu Schapira; Cheryl H Arrowsmith; Masoud Vedadi
Journal:  Biochem J       Date:  2013-01-01       Impact factor: 3.857
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.