Literature DB >> 26167276

Synthesis and bioactivity of nobilamide B.

M P V Jacinto1, M S Flores2, Z Lin3, G P Concepcion2, E W Schmidt3, S Faulkner4, A J L Villaraza1.   

Abstract

An alternative and facile solution/solid-phase approach is reported for the total synthesis of neuroactive peptide, nobilamide B. Z-Dhb was formed in solution via EDC/CuCl induced elimination. The solid-phase synthesis employed HBTU/Oxyma Pure™ coupling using Barlos resin. Synthetic nobilamide B was also found to be neuroactive in primary cultures of dorsal root ganglion (DRG) neurons.

Entities:  

Year:  2014        PMID： 26167276      PMCID： PMC4497583          DOI： 10.1039/C4RA06873D

Source DB:  PubMed          Journal:  RSC Adv        ISSN： 2046-2069            Impact factor:   3.361


  8 in total

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Journal:  J Neurophysiol       Date:  2008-05-28       Impact factor: 2.714

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Authors:  A López-Macià; J C Jiménez; M Royo; E Giralt; F Albericio
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Authors:  Zhenjian Lin; Christopher A Reilly; Rowena Antemano; Ronald W Hughen; Lenny Marett; Gisela P Concepcion; Margo G Haygood; Baldomero M Olivera; Alan Light; Eric W Schmidt
Journal:  J Med Chem       Date:  2011-05-16       Impact factor: 7.446
  8 in total
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1.  On the inhibition of capsaicin response in dorsal root ganglion neurons by nobilamide B and analogues: a structure-activity relationship study.

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Journal:  Medchemcomm       Date:  2018-08-15       Impact factor: 3.597
  1 in total

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