Irmela Mantel1, Christina Gianniou, Ali Dirani. 1. *Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland; and †Medical Retina Clinic, Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland.
Abstract
PURPOSE: To compare the effects of converting to aflibercept therapy with continuing ranibizumab therapy in eyes with neovascular age-related macular degeneration requiring monthly ranibizumab treatment. METHODS:Patients were selected from the 104 patients (115 eyes) already enrolled in an "Observe and Plan" prospective case series that included treating neovascular age-related macular degeneration with ranibizumab for 24 months. Patients who still needed monthly retreatment at the end of a 2-year study were randomized to either continue ranibizumab therapy or to convert to aflibercept therapy. Outcome measures included average interval between treatments, resolution of exudative signs, number of retreatments, and change in visual acuity over 12 months (the third treatment year). RESULTS:Nineteen patients (21 eyes) met the inclusion criteria. Ten eyes were randomized to receive aflibercept, and 11 eyes remained on ranibizumab. Groups were balanced for baseline characteristics. Outcomes were similar in the 2 groups over a 12-month study duration, with no statistical difference. CONCLUSION: This comparative pilot study suggests that neovascular age-related macular degeneration requiring monthly retreatment withranibizumab may respond in similar ways to both ranibizumab and aflibercept treatment. Larger sample sizes would be needed to confirm this observation.
RCT Entities:
PURPOSE: To compare the effects of converting to aflibercept therapy with continuing ranibizumab therapy in eyes with neovascular age-related macular degeneration requiring monthly ranibizumab treatment. METHODS:Patients were selected from the 104 patients (115 eyes) already enrolled in an "Observe and Plan" prospective case series that included treating neovascular age-related macular degeneration with ranibizumab for 24 months. Patients who still needed monthly retreatment at the end of a 2-year study were randomized to either continue ranibizumab therapy or to convert to aflibercept therapy. Outcome measures included average interval between treatments, resolution of exudative signs, number of retreatments, and change in visual acuity over 12 months (the third treatment year). RESULTS: Nineteen patients (21 eyes) met the inclusion criteria. Ten eyes were randomized to receive aflibercept, and 11 eyes remained on ranibizumab. Groups were balanced for baseline characteristics. Outcomes were similar in the 2 groups over a 12-month study duration, with no statistical difference. CONCLUSION: This comparative pilot study suggests that neovascular age-related macular degeneration requiring monthly retreatment with ranibizumab may respond in similar ways to both ranibizumab and aflibercept treatment. Larger sample sizes would be needed to confirm this observation.
Authors: Theodoros Empeslidis; Matthew Storey; Theodoros Giannopoulos; Vassileios Konidaris; Paris G Tranos; Evangelia S Panagiotou; Irini C Voudouragkaki; Anastasios G Konstas Journal: Adv Ther Date: 2019-05-17 Impact factor: 3.845
Authors: Alfredo García-Layana; Marta S Figueroa; Javier Araiz; José M Ruiz-Moreno; Francisco Gómez-Ulla; Luis Arias-Barquet; Nicholas Reiter Journal: Drugs Aging Date: 2015-10 Impact factor: 3.923
Authors: Richard P Gale; Ian Pearce; Nicole Eter; Faruque Ghanchi; Frank G Holz; Steffen Schmitz-Valckenberg; Konstantinos Balaskas; Ben J L Burton; Susan M Downes; Haralabos Eleftheriadis; Sheena George; David Gilmour; Robin Hamilton; Andrew J Lotery; Nishal Patel; Priya Prakash; Cynthia Santiago; Saju Thomas; Deepali Varma; Gavin Walters; Michael Williams; Armin Wolf; Rosina H Zakri; Franklin Igwe; Filis Ayan Journal: Br J Ophthalmol Date: 2019-08-05 Impact factor: 4.638