Murad Atmaca1, Hanefi Yildirim2, Seda Yilmaz1, Neslihan Caglar1, Osman Mermi1, M Gurkan Gurok3, Yasemin Kekilli4, Hakan Turkcapar5. 1. a Department of Psychiatry , School of Medicine, Firat University , Elazig , Turkey. 2. b Department of Radiology , School of Medicine, Firat University , Elazig , Turkey. 3. c Elazig Mental Health Hospital , Elazig , Turkey. 4. d Yildirim Beyazit Diskapı Educationald and Investigational Hospital , Ankara , Turkey. 5. e Department of Psychiatry , School of Medicine, Hasan Kalyoncu University , Istanbul , Turkey.
Abstract
OBJECTIVE: In the present study, we examined the effects of cognitive behavioral therapy (CBT) on the hippocampal neurochemistry in patients with obsessive-compulsive disorder (OCD). METHODS: Twelve patients with OCD and same number of healthy controls were included into the study. Neurochemical variables of the hippocampus were measured before and after the CBT treatment in the patient group. RESULTS: At baseline, the patients with OCD had significantly lower ratio of N-acetyl-l-aspartate/choline (NAA/CHO) compared with that of healthy control subjects. When comparing pre-treatment results of the patient group with those of post-treatment ones using paired t-test, we found that NAA/CHO ratio increased from 2.47 ± 0.64 to 3.66 ± 0.88, with a statisical significance. CONCLUSIONS: The findings may implicate that CBT increases the level of NAA which is a marker of neuronal integrity.
OBJECTIVE: In the present study, we examined the effects of cognitive behavioral therapy (CBT) on the hippocampal neurochemistry in patients with obsessive-compulsive disorder (OCD). METHODS: Twelve patients with OCD and same number of healthy controls were included into the study. Neurochemical variables of the hippocampus were measured before and after the CBT treatment in the patient group. RESULTS: At baseline, the patients with OCD had significantly lower ratio of N-acetyl-l-aspartate/choline (NAA/CHO) compared with that of healthy control subjects. When comparing pre-treatment results of the patient group with those of post-treatment ones using paired t-test, we found that NAA/CHO ratio increased from 2.47 ± 0.64 to 3.66 ± 0.88, with a statisical significance. CONCLUSIONS: The findings may implicate that CBT increases the level of NAA which is a marker of neuronal integrity.
Authors: Ákos Pertich; Gabriella Eördegh; Laura Németh; Orsolya Hegedüs; Dorottya Öri; András Puszta; Péter Nagy; Szabolcs Kéri; Attila Nagy Journal: Front Psychiatry Date: 2020-11-26 Impact factor: 4.157