Zahra Movahed1, Leila Kohan2, Sara Fallahi3, Omid Tabiee4. 1. Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran. 2. Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran. Electronic address: Kohan@iaua.ac.ir. 3. Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. 4. Department of Natural Resources, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran.
Abstract
OBJECTIVE: The purpose of this study was to assess the association between the rs17173608 chemerin polymorphism and polycystic ovary syndrome risk (PCOS). MATERIALS AND METHODS: This case-control study was performed on 150 patients with PCOS and 150 normal women as the control group. Tetra-amplification refractory mutation system-polymerase chain reaction was used to detect the polymorphism. RESULTS: Our finding showed a positive association between the chemerin gene rs17173608 polymorphism and risk of PCOS. In the dominant effect of the G allele (comparison between TG+GG and TT), TG+GG genotypes were associated with the risk of PCOS (odds ratio = 2; 95% confidence interval = 1.3-3.2, p = 0.003). The G allele is thus dominant and increases the risk of PCOS as compared to the T allele (odds ratio = 1.7, 95% confidence interval = 1.1-2.5, p = 0.009). Nonetheless, there was no significant association between chemerin rs17173608 gene polymorphism and PCOS after adjusting genotypes for body mass index and age. CONCLUSION: These results suggested that there was a significant association between chemerin rs17173608 polymorphism and the PCOS; but this relationship was affected by obesity status.
OBJECTIVE: The purpose of this study was to assess the association between the rs17173608chemerin polymorphism and polycystic ovary syndrome risk (PCOS). MATERIALS AND METHODS: This case-control study was performed on 150 patients with PCOS and 150 normal women as the control group. Tetra-amplification refractory mutation system-polymerase chain reaction was used to detect the polymorphism. RESULTS: Our finding showed a positive association between the chemerin gene rs17173608 polymorphism and risk of PCOS. In the dominant effect of the G allele (comparison between TG+GG and TT), TG+GG genotypes were associated with the risk of PCOS (odds ratio = 2; 95% confidence interval = 1.3-3.2, p = 0.003). The G allele is thus dominant and increases the risk of PCOS as compared to the T allele (odds ratio = 1.7, 95% confidence interval = 1.1-2.5, p = 0.009). Nonetheless, there was no significant association between chemerinrs17173608 gene polymorphism and PCOS after adjusting genotypes for body mass index and age. CONCLUSION: These results suggested that there was a significant association between chemerinrs17173608 polymorphism and the PCOS; but this relationship was affected by obesity status.