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Literature DB >> 26165999

Nitroreductase-triggered activation of a novel caged fluorescent probe obtained from methylene blue.

Jungeun Bae¹, Louis E McNamara, Manal A Nael, Fakhri Mahdi, Robert J Doerksen, Gene L Bidwell, Nathan I Hammer, Seongbong Jo.

Abstract

A near-infrared fluorescent probe based on methylene blue (p-NBMB) was developed for the detection of nitroreductase. Conjugating methylene blue with a p-nitrobenzyl moiety enables it to be activated by nitroreductase-catalyzed 1,6-elimination, resulting in the release of an active methylene blue fluorophore.

Entities: Chemical Disease Species

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Year: 2015 PMID： 26165999 PMCID： PMC4547460 DOI： 10.1039/c5cc03824c

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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