| Literature DB >> 26165243 |
Pham Bich Ngoc1, Thanh Binh Pham2, Hai Dang Nguyen2, Thu Trang Tran1, Hoang Ha Chu1, Van Minh Chau2, Jeong-Hyung Lee3, Tien Dat Nguyen2.
Abstract
One new β-carboline alkaloid 7-methoxy-(9H-β-carbolin-1-il)-(E)-1-propenoic acid (1) together with 9-methoxycanthin-6-one (2) and 9-hydroxycanthin-6-one (3) were isolated from the hairy-root cultures of Eurycoma longifolia. The effects of these compounds on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells were investigated. Compound 1 strongly inhibited the production of NO while 2 and 3 having weak or inactive effect. Consistently, compound 1 decreased the expression of cyclooxygenase-2 and inducible nitric oxide synthase.Entities:
Keywords: Eurycoma longifolia; hairy-root cultures; β-carboline alkaloid
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Year: 2015 PMID： 26165243 DOI： 10.1080/14786419.2015.1056187
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.861