PURPOSE: To report successful treatment of a fine-needle aspiration biopsy-proven acquired retinal astrocytoma with photodynamic therapy. METHODS: Case report. RESULTS: A 50-year-old man complaining of decreased vision of his right eye was found to have a visual acuity of 20/100 and an amelanotic juxtapapillary retinal tumor with surrounding subretinal fluid and lipid exudation extending into the fovea. Fine-needle aspiration biopsy showed an astrocytic lesion consistent with retinal astrocytoma. The lesion was treated with one session of photodynamic therapy. At 20 months after photodynamic therapy, visual acuity had improved to 20/20 with complete tumor regression and normal foveal contour on optical coherence tomography. CONCLUSION: This report confirms that photodynamic therapy of symptomatic acquired retinal astrocytoma may be effective in causing tumor regression and stabilizing or improving visual acuity by reducing tumor leakage.
PURPOSE: To report successful treatment of a fine-needle aspiration biopsy-proven acquired retinal astrocytoma with photodynamic therapy. METHODS: Case report. RESULTS: A 50-year-old man complaining of decreased vision of his right eye was found to have a visual acuity of 20/100 and an amelanotic juxtapapillary retinal tumor with surrounding subretinal fluid and lipid exudation extending into the fovea. Fine-needle aspiration biopsy showed an astrocytic lesion consistent with retinal astrocytoma. The lesion was treated with one session of photodynamic therapy. At 20 months after photodynamic therapy, visual acuity had improved to 20/20 with complete tumor regression and normal foveal contour on optical coherence tomography. CONCLUSION: This report confirms that photodynamic therapy of symptomatic acquired retinal astrocytoma may be effective in causing tumor regression and stabilizing or improving visual acuity by reducing tumor leakage.
Authors: Anne Marie Barrette; Halle Ronk; Tanvi Joshi; Zarmeen Mussa; Meenakshi Mehrotra; Alexandros Bouras; German Nudelman; Joe Gerald Jesu Raj; Dominique Bozec; William Lam; Jane Houldsworth; Raymund Yong; Elena Zaslavsky; Constantinos G Hadjipanayis; Marc R Birtwistle; Nadejda M Tsankova Journal: Neuro Oncol Date: 2022-05-04 Impact factor: 13.029