Luis Rojo-Moreno1, Carmen Iranzo-Tatay2, Natalia Gimeno-Clemente3, Maria Antonia Barberá-Fons4, Luis Miguel Rojo-Bofill4, Lorenzo Livianos-Aldana1. 1. Servicio de Psiquiatría, Hospital Universitario y Politécnico La Fe, Valencia, España; CIBERESP, España; Departamento de Psiquiatría, Facultad de Medicina, Universidad de Valencia, Valencia, España. 2. Servicio de Psiquiatría, Hospital Universitario y Politécnico La Fe, Valencia, España. Electronic address: iranzotatay@hotmail.com. 3. Grupo de investigación Psiquiátrica, Sección de Psiquiatría Infanto-Juvenil, Hospital Universitario La Fe, Valencia, España. 4. Servicio de Psiquiatría, Hospital Universitario y Politécnico La Fe, Valencia, España.
Abstract
INTRODUCTION: The heritability of eating disorders has been estimated to range from 22% to over 62%.The aim of this study is to determine the relative influence of genetics and environment that contribute to the drive for thinness, body dissatisfaction, perfectionism, and ineffectiveness, by evaluating sex differences in a sample of adolescent twins from Valencia, Spain. MATERIAL AND METHODS: Five hundred eighty-four pairs of adolescent twins between 13 and 18 years of age completed the study. To determine zygosity, teachers responded to a questionnaire on physical similarity. Psychological traits of eating disorders were assessed with four sub-scales of the Eating Disorder Inventory (EDI); drive for thinness, body dissatisfaction, perfectionism, and ineffectiveness. Twin models were used to assess genetic and environmental (common and unique) factors affecting these four psychological traits. RESULTS: All four traits showed significant genetic contributions among girls, with heritability estimates of 37.7% for ineffectiveness, 42.8% for perfectionism, 56.9% for drive for thinness, and 65.5% for body dissatisfaction. Among boys, body dissatisfaction showed no additive genetic contributions, indicating significant shared and individual specific environment effects. The three other traits in boys showed significant additive genetic contributions, but were lower than in girls. CONCLUSIONS: With the exception of body dissatisfaction in boys, psychological traits of eating disorders show heritability patterns that differ according to sex.
INTRODUCTION: The heritability of eating disorders has been estimated to range from 22% to over 62%.The aim of this study is to determine the relative influence of genetics and environment that contribute to the drive for thinness, body dissatisfaction, perfectionism, and ineffectiveness, by evaluating sex differences in a sample of adolescent twins from Valencia, Spain. MATERIAL AND METHODS: Five hundred eighty-four pairs of adolescent twins between 13 and 18 years of age completed the study. To determine zygosity, teachers responded to a questionnaire on physical similarity. Psychological traits of eating disorders were assessed with four sub-scales of the Eating Disorder Inventory (EDI); drive for thinness, body dissatisfaction, perfectionism, and ineffectiveness. Twin models were used to assess genetic and environmental (common and unique) factors affecting these four psychological traits. RESULTS: All four traits showed significant genetic contributions among girls, with heritability estimates of 37.7% for ineffectiveness, 42.8% for perfectionism, 56.9% for drive for thinness, and 65.5% for body dissatisfaction. Among boys, body dissatisfaction showed no additive genetic contributions, indicating significant shared and individual specific environment effects. The three other traits in boys showed significant additive genetic contributions, but were lower than in girls. CONCLUSIONS: With the exception of body dissatisfaction in boys, psychological traits of eating disorders show heritability patterns that differ according to sex.
Authors: María Laura Parra-Fernandez; Teresa Rodríguez-Cano; María Dolores Onieva-Zafra; Maria José Perez-Haro; Víctor Casero-Alonso; Juan Carlos Muñoz Camargo; Blanca Notario-Pacheco Journal: PLoS One Date: 2018-01-10 Impact factor: 3.240
Authors: María Laura Parra-Fernández; María Dolores Onieva-Zafra; Juan José Fernández-Muñoz; Elia Fernández-Martínez Journal: PLoS One Date: 2019-05-07 Impact factor: 3.240
Authors: C Iranzo-Tatay; D Hervas-Marin; J Sandoval; L Rojo-Moreno; L M Rojo-Bofill; D Garcia; F J Vaz-Leal; I Calabria; L Beato-Fernandez; S Oltra Journal: Transl Psychiatry Date: 2022-01-10 Impact factor: 7.989