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Literature DB >> 26163756

Targeting female hormone receptors as cervical cancer therapy.

Abstract

While preventive methods for cervical cancer are effective, available therapies for advanced cervical cancers are ineffective. New experimental evidence points to weaknesses of prior studies and provides fresh molecular insights on the opposing roles of estrogen receptor alpha (ERα) and the progesterone receptor (PR) that may be translated into valuable treatments for a subset of cervical cancers.

Entities: CellLine Chemical Disease Gene Species

Keywords: cervical cancer; estrogen receptor α; hormonal therapy; human papillomavirus; progesterone receptor

Mesh：

Substances：

Year: 2015 PMID： 26163756 PMCID： PMC4526440 DOI： 10.1016/j.tem.2015.06.004

Source DB: PubMed Journal: Trends Endocrinol Metab ISSN： 1043-2760 Impact factor: 12.015

13 in total

Review 1. Estrogen and ERalpha: culprits in cervical cancer?

Authors: Sang-Hyuk Chung; Silvia Franceschi; Paul F Lambert
Journal: Trends Endocrinol Metab Date: 2010-04-22 Impact factor: 12.015

2. Treatment with vaginal progesterone in women with low-grade cervical dysplasia: a phase II trial.

Authors: Lukas Hefler; Christoph Grimm; Clemens Tempfer; Alexander Reinthaller
Journal: Anticancer Res Date: 2010-04 Impact factor: 2.480

3. Estrogen and progesterone receptor expression in HPV-positive and HPV-negative cervical carcinomas.

Authors: Anna Kwasniewska; Krzysztof Postawski; Anna Gozdzicka-Jozefiak; Wojciech Kwasniewski; Ewelina Grywalska; Malgorzata Zdunek; Elzbieta Korobowicz
Journal: Oncol Rep Date: 2011-04-12 Impact factor: 3.906

4. Requirement for stromal estrogen receptor alpha in cervical neoplasia.

Authors: Sang-Hyuk Chung; Myeong Kyun Shin; Kenneth S Korach; Paul F Lambert
Journal: Horm Cancer Date: 2012-10-13 Impact factor: 3.869

5. Depot-medroxyprogesterone acetate and combined oral contraceptive use and cervical neoplasia among women with oncogenic human papillomavirus infection.

Authors: Tiffany G Harris; Leslie Miller; Shalini L Kulasingam; Qinghua Feng; Nancy B Kiviat; Stephen M Schwartz; Laura A Koutsky
Journal: Am J Obstet Gynecol Date: 2009-05 Impact factor: 8.661

6. Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study.

Authors: Margaret R E McCredie; Katrina J Sharples; Charlotte Paul; Judith Baranyai; Gabriele Medley; Ronald W Jones; David C G Skegg
Journal: Lancet Oncol Date: 2008-04-11 Impact factor: 41.316

7. Molecular transitions from papillomavirus infection to cervical precancer and cancer: Role of stromal estrogen receptor signaling.

Authors: Johan A den Boon; Dohun Pyeon; Sophia S Wang; Mark Horswill; Mark Schiffman; Mark Sherman; Rosemary E Zuna; Zhishi Wang; Stephen M Hewitt; Rachel Pearson; Meghan Schott; Lisa Chung; Qiuling He; Paul Lambert; Joan Walker; Michael A Newton; Nicolas Wentzensen; Paul Ahlquist
Journal: Proc Natl Acad Sci U S A Date: 2015-06-08 Impact factor: 11.205

8. Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development.

Authors: Laura Ciarloni; Sonia Mallepell; Cathrin Brisken
Journal: Proc Natl Acad Sci U S A Date: 2007-03-16 Impact factor: 11.205

9. Estrogen receptor, progesterone receptor, and bcl-2 are markers with prognostic significance in CIN III.

Authors: J A Fonseca-Moutinho; E Cruz; L Carvalho; H J M Prazeres; M M P de Lacerda; D P da Silva; F Mota; C F de Oliveira
Journal: Int J Gynecol Cancer Date: 2004 Sep-Oct Impact factor: 3.437

10. Amphiregulin mediates estrogen, progesterone, and EGFR signaling in the normal rat mammary gland and in hormone-dependent rat mammary cancers.

Authors: Anastasia Kariagina; Jianwei Xie; Jeffrey R Leipprandt; Sandra Z Haslam
Journal: Horm Cancer Date: 2010-11-23 Impact factor: 3.869

12 in total

Review 1. A Systematic Review and Meta-analysis of the Adverse Effects of Levonorgestrel Emergency Oral Contraceptive.

Authors: Nattawut Leelakanok; Janthima Methaneethorn
Journal: Clin Drug Investig Date: 2020-05 Impact factor: 2.859

2. Association of Estrogen Receptor Alpha Expression With Survival in Oropharyngeal Cancer Following Chemoradiation Therapy.

Authors: Maria B Koenigs; Armida Lefranc-Torres; Juliana Bonilla-Velez; Krupal B Patel; D Neil Hayes; Krzysztof Glomski; Paul M Busse; Annie W Chan; John R Clark; Daniel G Deschler; Kevin S Emerick; Rebecca J Hammon; Lori J Wirth; Derrick T Lin; Edmund A Mroz; William C Faquin; James W Rocco
Journal: J Natl Cancer Inst Date: 2019-09-01 Impact factor: 13.506

3. Epithelial oestrogen receptor α is dispensable for the development of oestrogen-induced cervical neoplastic diseases.

Authors: Jieun Son; Yuri Park; Sang-Hyuk Chung
Journal: J Pathol Date: 2018-04-03 Impact factor: 7.996

4. Estrogen Inhibits Epithelial Progesterone Receptor-Dependent Progestin Therapy Efficacy in a Mouse Model of Cervical Cancer.

Authors: Seunghan Baik; Fabiola F Mehta; Esra Unsal; Yuri Park; Sang-Hyuk Chung
Journal: Am J Pathol Date: 2021-11-10 Impact factor: 4.307

5. SERMs suppresses the growth of ERα positive cervical cancer xenografts through predominant inhibition of extra-nuclear ERα expression.

Authors: Balaji Ramachandran; Kanchan Murhekar; Shirley Sundersingh
Journal: Am J Cancer Res Date: 2021-06-15 Impact factor: 6.166