Lana A Faraj1, Dalia G Said2, Mohamed Al-Aqaba1, Ahmad M Otri1, Harminder S Dua1. 1. Division of Clinical Neuroscience, Department of Ophthalmology, University of Nottingham, Nottingham, UK. 2. Division of Clinical Neuroscience, Department of Ophthalmology, University of Nottingham, Nottingham, UK Department of Cornea and External Eye Diseases, Research Institute of Ophthalmology, Cairo, Egypt.
Abstract
BACKGROUND/AIMS: To clinically characterise corneal neovascularisation (CVas) with a view to elaborate clinical presentations and to standardise descriptors for clinical evaluation and research. METHODS: Corneas of 165 patients with CVas due to a variety of corneal pathologies were observed clinically with the slit lamp biomicroscope and photography at different time points over the course of their disease. Parameters assessed included location, depth, length, branching pattern, colour, lipid leakage, nature of blood flow and presence of haemorrhage. A clinical grading of CVas was applied. RESULTS: CVas can arise from the limbus, conjunctiva and iris. CVas preferentially travels along planes created by corneal incisions, suture tracks and lamellar keratoplasty, both deep lamellar and endothelial keratoplasty. CVas also principally follows the depth of pathology. CVas can be classified into active young, active old, mature, partially regressed and regressed. Herpetic infection was the most common cause of lipid keratopathy. Acanthamoeba keratitis induced the least amount of vascularisation. A simple and efficient clinical grading system for ascertaining the severity of CVas was developed and validated. CONCLUSIONS: The various clinical characteristics of CVas described in this study can be used to standardise the nomenclature and description of CVas and clinically grade its severity. As modern, effective methods of treating CVas are being introduced, it is important that there is uniformity in the descriptors used to establish baseline values and evaluate outcomes of treatment. The parameters established in this study can help in this regard. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
BACKGROUND/AIMS: To clinically characterise corneal neovascularisation (CVas) with a view to elaborate clinical presentations and to standardise descriptors for clinical evaluation and research. METHODS: Corneas of 165 patients with CVas due to a variety of corneal pathologies were observed clinically with the slit lamp biomicroscope and photography at different time points over the course of their disease. Parameters assessed included location, depth, length, branching pattern, colour, lipid leakage, nature of blood flow and presence of haemorrhage. A clinical grading of CVas was applied. RESULTS: CVas can arise from the limbus, conjunctiva and iris. CVas preferentially travels along planes created by corneal incisions, suture tracks and lamellar keratoplasty, both deep lamellar and endothelial keratoplasty. CVas also principally follows the depth of pathology. CVas can be classified into active young, active old, mature, partially regressed and regressed. Herpetic infection was the most common cause of lipidkeratopathy. Acanthamoeba keratitis induced the least amount of vascularisation. A simple and efficient clinical grading system for ascertaining the severity of CVas was developed and validated. CONCLUSIONS: The various clinical characteristics of CVas described in this study can be used to standardise the nomenclature and description of CVas and clinically grade its severity. As modern, effective methods of treating CVas are being introduced, it is important that there is uniformity in the descriptors used to establish baseline values and evaluate outcomes of treatment. The parameters established in this study can help in this regard. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
Authors: Danial Roshandel; Medi Eslani; Alireza Baradaran-Rafii; Albert Y Cheung; Khaliq Kurji; Sayena Jabbehdari; Alejandra Maiz; Setareh Jalali; Ali R Djalilian; Edward J Holland Journal: Ocul Surf Date: 2018-06-20 Impact factor: 5.033
Authors: Christoph Palme; Vito Romano; Matthias Brunner; Riccardo Vinciguerra; Stephen B Kaye; Bernhard Steger Journal: Transl Vis Sci Technol Date: 2018-10-01 Impact factor: 3.283