Courtney Berezuk1,2,3, Joel Ramirez1,2,3, Fuqiang Gao1,2,3, Christopher J M Scott1,2,3, Menal Huroy1,2,3, Richard H Swartz1,2,3,4,5, Brian J Murray1,2,3,5, Sandra E Black1,2,3,4,5, Mark I Boulos1,2,3,5. 1. LC Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute (SRI), University of Toronto, Canada. 2. Heart & Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Site, Toronto, Canada. 3. Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre (HSC), Toronto, Canada. 4. Institute of Medical Science, Faculty of Medicine, School of Graduate Studies University of Toronto, Toronto, Canada. 5. Department of Medicine (Neurology), University of Toronto and Sunnybrook HSC, Toronto, Canada.
Abstract
STUDY OBJECTIVES: To test the hypothesis that enlarged Virchow-Robin space volumes (VRS) are associated with objective measures of poor quality sleep. DESIGN: Retrospective cross-sectional study. SETTING: Sunnybrook Health Sciences Centre. PATIENTS: Twenty-six patients being evaluated for cerebrovascular disease were assessed using polysomnography and high-resolution structural magnetic resonance imaging. MEASUREMENTS AND RESULTS: Regionalized VRS were quantified from three-dimensional high-resolution magnetic resonance imaging and correlated with measures of polysomnography-derived sleep parameters while controlling for age, stroke volume, body mass index, systolic blood pressure, and ventricular cerebrospinal fluid volume. Sleep efficiency was negatively correlated with total VRS (rho = -0.47, P = 0.03) and basal ganglia VRS (rho = -0.54, P = 0.01), whereas wake after sleep onset was positively correlated with basal ganglia VRS (rho = 0.52, P = 0.02). Furthermore, VRS in the basal ganglia were negatively correlated with duration of N3 (rho = -0.53, P = 0.01). CONCLUSIONS: These preliminary results suggest that sleep may play a role in perivascular clearance in ischemic brain disease, and invite future research into the potential relevance of Virchow-Robin spaces as an imaging biomarker for nocturnal metabolite clearance.
STUDY OBJECTIVES: To test the hypothesis that enlarged Virchow-Robin space volumes (VRS) are associated with objective measures of poor quality sleep. DESIGN: Retrospective cross-sectional study. SETTING: Sunnybrook Health Sciences Centre. PATIENTS: Twenty-six patients being evaluated for cerebrovascular disease were assessed using polysomnography and high-resolution structural magnetic resonance imaging. MEASUREMENTS AND RESULTS: Regionalized VRS were quantified from three-dimensional high-resolution magnetic resonance imaging and correlated with measures of polysomnography-derived sleep parameters while controlling for age, stroke volume, body mass index, systolic blood pressure, and ventricular cerebrospinal fluid volume. Sleep efficiency was negatively correlated with total VRS (rho = -0.47, P = 0.03) and basal ganglia VRS (rho = -0.54, P = 0.01), whereas wake after sleep onset was positively correlated with basal ganglia VRS (rho = 0.52, P = 0.02). Furthermore, VRS in the basal ganglia were negatively correlated with duration of N3 (rho = -0.53, P = 0.01). CONCLUSIONS: These preliminary results suggest that sleep may play a role in perivascular clearance in ischemic brain disease, and invite future research into the potential relevance of Virchow-Robin spaces as an imaging biomarker for nocturnal metabolite clearance.
Authors: Y-C Zhu; C Dufouil; B Mazoyer; A Soumaré; F Ricolfi; C Tzourio; H Chabriat Journal: AJNR Am J Neuroradiol Date: 2011-02-24 Impact factor: 3.825
Authors: A M J Maclullich; J M Wardlaw; K J Ferguson; J M Starr; J R Seckl; I J Deary Journal: J Neurol Neurosurg Psychiatry Date: 2004-11 Impact factor: 10.154
Authors: Alex E Roher; Yu-Min Kuo; Chera Esh; Carmen Knebel; Nicole Weiss; Walter Kalback; Dean C Luehrs; Jennifer L Childress; Thomas G Beach; Roy O Weller; Tyler A Kokjohn Journal: Mol Med Date: 2003 Mar-Apr Impact factor: 6.354
Authors: Ryan A Opel; Alison Christy; Erin L Boespflug; Kristianna B Weymann; Brendan Case; Jeffery M Pollock; Lisa C Silbert; Miranda M Lim Journal: J Cereb Blood Flow Metab Date: 2018-08-10 Impact factor: 6.200
Authors: Diego Z Carvalho; Erik K St Louis; Bradley F Boeve; Michelle M Mielke; Scott A Przybelski; David S Knopman; Mary M Machulda; Rosebud O Roberts; Yonas E Geda; Ronald C Petersen; Clifford R Jack; Prashanthi Vemuri Journal: Sleep Med Date: 2016-11-03 Impact factor: 3.492
Authors: J Piantino; E L Boespflug; D L Schwartz; M Luther; A M Morales; A Lin; R V Fossen; L Silbert; B J Nagel Journal: AJNR Am J Neuroradiol Date: 2020-10-08 Impact factor: 3.825
Authors: Michelle Olaithe; Maria Pushpanathan; David Hillman; Peter R Eastwood; Michael Hunter; Timothy Skinner; Alan James; Keith A Wesnes; Romola S Bucks Journal: J Clin Sleep Med Date: 2020-09-15 Impact factor: 4.062
Authors: François De Guio; Eric Jouvent; Geert Jan Biessels; Sandra E Black; Carol Brayne; Christopher Chen; Charlotte Cordonnier; Frank-Eric De Leeuw; Martin Dichgans; Fergus Doubal; Marco Duering; Carole Dufouil; Emrah Duzel; Franz Fazekas; Vladimir Hachinski; M Arfan Ikram; Jennifer Linn; Paul M Matthews; Bernard Mazoyer; Vincent Mok; Bo Norrving; John T O'Brien; Leonardo Pantoni; Stefan Ropele; Perminder Sachdev; Reinhold Schmidt; Sudha Seshadri; Eric E Smith; Luciano A Sposato; Blossom Stephan; Richard H Swartz; Christophe Tzourio; Mark van Buchem; Aad van der Lugt; Robert van Oostenbrugge; Meike W Vernooij; Anand Viswanathan; David Werring; Frank Wollenweber; Joanna M Wardlaw; Hugues Chabriat Journal: J Cereb Blood Flow Metab Date: 2016-05-11 Impact factor: 6.200
Authors: Rosalind Brown; Helene Benveniste; Sandra E Black; Serge Charpak; Martin Dichgans; Anne Joutel; Maiken Nedergaard; Kenneth J Smith; Berislav V Zlokovic; Joanna M Wardlaw Journal: Cardiovasc Res Date: 2018-09-01 Impact factor: 10.787
Authors: Joel Ramirez; Courtney Berezuk; Alicia A McNeely; Fuqiang Gao; JoAnne McLaurin; Sandra E Black Journal: Cell Mol Neurobiol Date: 2016-03-18 Impact factor: 5.046