M Miravitlles1, M Barrecheguren1, M Román-Rodríguez2. 1. Pneumology Department, Hospital General Universitari Vall d'Hebron, Ciber de Enfermedades Respiratorias (CIBERES), Barcelona, Spain. 2. Primary Health Care Center Son Pisà, Primary Care Respiratory Research Unit, Instituto de Investigación Sanitaria de Palma, Palma de Mallorca, Spain.
Abstract
SETTING: Clinical phenotypes of chronic obstructive pulmonary disease (COPD) identify patients with common characteristics. OBJECTIVES: To investigate the distribution of four different COPD phenotypes: non-exacerbators, patients with asthma-COPD overlap syndrome (ACOS), exacerbators with chronic bronchitis and those without, we analysed the impact of COPD on quality of life (HRQoL), and on anxiety and depression in these phenotypes. DESIGN: Observational, multicentre study conducted among 3125 COPD patients recruited from out-patient clinics in Barcelona, Spain. Phenotyping was performed based on the clinical information available. The COPD Assessment Test and EuroQoL-5 Dimensions questionnaire were used to evaluate HRQoL; patient mood was evaluated using the Hospital Anxiety and Depression Scale (HADS). RESULTS: The distribution of phenotypes was as follows: 60.6% non-exacerbators, 15.9% ACOS patients, 19.3% exacerbators with chronic bronchitis and 4.3% exacerbators without chronic bronchitis. Non-exacerbators had milder COPD, whereas exacerbators presented with the most severe disease, with little difference between those with and those without chronic bronchitis. ACOS patients were more frequently female with better lung function, but more impaired HRQoL and greater anxiety and depression, than non-exacerbators. CONCLUSIONS: Almost two thirds of COPD patients are non-exacerbators, and 15.9% have ACOS. Different phenotypes showed different demographic and clinical characteristics as well as impact on HRQoL and mood.
SETTING: Clinical phenotypes of chronic obstructive pulmonary disease (COPD) identify patients with common characteristics. OBJECTIVES: To investigate the distribution of four different COPD phenotypes: non-exacerbators, patients with asthma-COPD overlap syndrome (ACOS), exacerbators with chronic bronchitis and those without, we analysed the impact of COPD on quality of life (HRQoL), and on anxiety and depression in these phenotypes. DESIGN: Observational, multicentre study conducted among 3125 COPDpatients recruited from out-patient clinics in Barcelona, Spain. Phenotyping was performed based on the clinical information available. The COPD Assessment Test and EuroQoL-5 Dimensions questionnaire were used to evaluate HRQoL; patient mood was evaluated using the Hospital Anxiety and Depression Scale (HADS). RESULTS: The distribution of phenotypes was as follows: 60.6% non-exacerbators, 15.9% ACOS patients, 19.3% exacerbators with chronic bronchitis and 4.3% exacerbators without chronic bronchitis. Non-exacerbators had milder COPD, whereas exacerbators presented with the most severe disease, with little difference between those with and those without chronic bronchitis. ACOS patients were more frequently female with better lung function, but more impaired HRQoL and greater anxiety and depression, than non-exacerbators. CONCLUSIONS: Almost two thirds of COPDpatients are non-exacerbators, and 15.9% have ACOS. Different phenotypes showed different demographic and clinical characteristics as well as impact on HRQoL and mood.
Authors: Cristina Esquinas; Maria A Ramon; Alexa Nuñez; Jesús Molina; José A Quintano; Miguel Roman-Rodríguez; Karlos Naberan; Carl Llor; Carlos Roncero; Marc Miravitlles; Miriam Barrecheguren Journal: Qual Life Res Date: 2019-10-31 Impact factor: 4.147
Authors: Marc Miravitlles; Bernardino Alcázar; Francisco Javier Alvarez; Teresa Bazús; Myriam Calle; Ciro Casanova; Carolina Cisneros; Juan P de-Torres; Luis M Entrenas; Cristóbal Esteban; Patricia García-Sidro; Borja G Cosio; Arturo Huerta; Milagros Iriberri; José Luis Izquierdo; Antolín López-Viña; José Luis López-Campos; Eva Martínez-Moragón; Luis Pérez de Llano; Miguel Perpiñá; José Antonio Ros; José Serrano; Juan José Soler-Cataluña; Alfons Torrego; Isabel Urrutia; Vicente Plaza Journal: Int J Chron Obstruct Pulmon Dis Date: 2015-07-15
Authors: Marc Miravitlles; Borja G Cosío; Aurelio Arnedillo; Myriam Calle; Bernardino Alcázar-Navarrete; Cruz González; Cristóbal Esteban; Juan Antonio Trigueros; José Miguel Rodríguez González-Moro; José Antonio Quintano Jiménez; Adolfo Baloira Journal: Respir Res Date: 2017-11-28
Authors: Juan Antonio Riesco; Bernardino Alcázar; Juan Antonio Trigueros; Anna Campuzano; Joselín Pérez; José Luis Lorenzo Journal: Int J Chron Obstruct Pulmon Dis Date: 2017-07-06
Authors: Borja G Cosio; Joan B Soriano; Jose Luis López-Campos; Myriam Calle; Juan José Soler; Juan Pablo de-Torres; Jose Maria Marín; Cristina Martínez; Pilar de Lucas; Isabel Mir; Germán Peces-Barba; Nuria Feu-Collado; Ingrid Solanes; Inmaculada Alfageme Journal: PLoS One Date: 2016-09-29 Impact factor: 3.240