| Literature DB >> 26162246 |
Monica Mendes Kangussu-Marcolino1, Marianna Maia Taulois do Rosário1, Miguel Daniel Noseda1, Maria Eugenia Rabello Duarte1, Diogo Ricardo Bazan Ducatti1, Juliana Emanuela Fogari Cassolato1, Marcello Iacomini2, Glaucia Regina Martinez1, Maria Eliane Merlin Rocha1, Silvia Maria Suter Correia Cadena1, Guilhermina Rodrigues Noleto1.
Abstract
The present study investigated in vitro the effects of sulphated heterorhamnan (Go3), iota-/nu-carrageenans (G3d and EHW-I) and arabinogalactan (ARAGAL) polysaccharides on macrophage activation and inhibition of intracellular amastigotes of Leishmania (L.) amazonensis. All the sulphated polysaccharides (Go3, G3d and EHW-I) promoted increased nitric oxide production varying from 71 to 110%. The leishmanicidal activity of all compounds was compared to the inhibition effect of Meglumine Antimoniate at 300μg/mL (∼79%), used as positive control. Inhibition of Leishmania (L.) amazonensis growth was 55% with 5μg/mL of Go3, 50% and 98% to G3d and EHW-I, respectively at 10μg/mL, and 88% with 10μg/mL of ARAGAL. The superoxide anion scavenging activity for the sulphated polysaccharides varied from approximately 30-55% at 10μg/mL. In conclusion, the results of the present study indicate the promising potential of these polysaccharides for the development of new alternative therapeutic agents against leishmaniasis.Entities:
Keywords: Leishmania; Macrophages; Polysaccharides
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Year: 2015 PMID： 26162246 DOI： 10.1016/j.ijbiomac.2015.07.006
Source DB: PubMed Journal: Int J Biol Macromol ISSN： 0141-8130 Impact factor: 6.953