Lauren Marussich1, Fabrice Manns1, Derek Nankivil2, Bianca Maceo Heilman1, Yue Yao1, Esdras Arrieta-Quintero2, Arthur Ho3, Robert Augusteyn3, Jean-Marie Parel1. 1. Ophthalmic Biophysics Center Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States 2Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami, College of Engineeri. 2. Ophthalmic Biophysics Center Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States. 3. Ophthalmic Biophysics Center Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States 3Brien Holden Vision Institute and Vision Cooperative Research Centre, Sydney, Australia 4School of Optometry and Vision.
Abstract
PURPOSE: To determine if the lens volume changes during accommodation. METHODS: The study used data acquired on 36 cynomolgus monkey lenses that were stretched in a stepwise fashion to simulate disaccommodation. At each step, stretching force and dioptric power were measured and a cross-sectional image of the lens was acquired using an optical coherence tomography system. Images were corrected for refractive distortions and lens volume was calculated assuming rotational symmetry. The average change in lens volume was calculated and the relation between volume change and power change, and between volume change and stretching force, were quantified. Linear regressions of volume-power and volume-force plots were calculated. RESULTS: The mean (± SD) volume in the unstretched (accommodated) state was 97 ± 8 mm3. On average, there was a small but statistically significant (P = 0.002) increase in measured lens volume with stretching. The mean change in lens volume was +0.8 ± 1.3 mm3. The mean volume-power and volume-load slopes were -0.018 ± 0.058 mm3/D and +0.16 ± 0.40 mm3/g. CONCLUSIONS: Lens volume remains effectively constant during accommodation, with changes that are less than 1% on average. This result supports a hypothesis that the change in lens shape with accommodation is accompanied by a redistribution of tissue within the capsular bag without significant compression of the lens contents or fluid exchange through the capsule.
PURPOSE: To determine if the lens volume changes during accommodation. METHODS: The study used data acquired on 36 cynomolgus monkey lenses that were stretched in a stepwise fashion to simulate disaccommodation. At each step, stretching force and dioptric power were measured and a cross-sectional image of the lens was acquired using an optical coherence tomography system. Images were corrected for refractive distortions and lens volume was calculated assuming rotational symmetry. The average change in lens volume was calculated and the relation between volume change and power change, and between volume change and stretching force, were quantified. Linear regressions of volume-power and volume-force plots were calculated. RESULTS: The mean (± SD) volume in the unstretched (accommodated) state was 97 ± 8 mm3. On average, there was a small but statistically significant (P = 0.002) increase in measured lens volume with stretching. The mean change in lens volume was +0.8 ± 1.3 mm3. The mean volume-power and volume-load slopes were -0.018 ± 0.058 mm3/D and +0.16 ± 0.40 mm3/g. CONCLUSIONS: Lens volume remains effectively constant during accommodation, with changes that are less than 1% on average. This result supports a hypothesis that the change in lens shape with accommodation is accompanied by a redistribution of tissue within the capsular bag without significant compression of the lens contents or fluid exchange through the capsule.
Authors: Bianca M Maceo; Fabrice Manns; David Borja; Derek Nankivil; Stephen Uhlhorn; Esdras Arrieta; Arthur Ho; Robert C Augusteyn; Jean-Marie Parel Journal: J Vis Date: 2011-11-30 Impact factor: 2.240
Authors: Aldo C Zamudio; Oscar A Candia; Chi Wing Kong; Brian Wu; Rosana Gerometta Journal: Am J Physiol Cell Physiol Date: 2008-04-02 Impact factor: 4.249
Authors: David Borja; Damian Siedlecki; Alberto de Castro; Stephen Uhlhorn; Sergio Ortiz; Esdras Arrieta; Jean-Marie Parel; Susana Marcos; Fabrice Manns Journal: Biomed Opt Express Date: 2010-11-08 Impact factor: 3.732
Authors: Emilia M Méndez-Aguilar; Ismael Kelly-Pérez; L R Berriel-Valdos; José A Delgado-Atencio Journal: Biomed Opt Express Date: 2017-05-19 Impact factor: 3.732
Authors: Ashik Mohamed; Sushma Nandyala; Eduardo Martinez-Enriquez; Bianca Maceo Heilman; Robert C Augusteyn; Alberto de Castro; Marco Ruggeri; Jean-Marie A Parel; Susana Marcos; Fabrice Manns Journal: Exp Eye Res Date: 2021-02-03 Impact factor: 3.467