Mengyuan Ge1, Zhen Gui, Xiaoming Wang, Feng Yan. 1. a Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing Medical University Cancer Hospital & Jiangsu Cancer Hospital , Nanjing , China.
Abstract
OBJECTIVE: To analyze the Ubiquitin-like with PHD and ring finger domains (UHRF) 1 expression in gastric cancer (GC). METHODS: The concentrations of UHRF1 DNA in serum were compared between 187 GC patients and 56 healthy controls using real-time PCR. Immunohistochemical analysis using tissue microarrays was performed. RESULTS: UHRF1 DNA levels were significantly higher in GC patients compared to healthy controls (p < 0.001) and have associations with age and lymph node metastasis (LNM). The UHRF1 expression was significantly higher in tumor tissue than matched normal tissues (p < 0.001). CONCLUSIONS: The UHRF1 expression in serum and tissue may represent a novel biomarker for GC diagnosis and prognosis.
OBJECTIVE: To analyze the Ubiquitin-like with PHD and ring finger domains (UHRF) 1 expression in gastric cancer (GC). METHODS: The concentrations of UHRF1 DNA in serum were compared between 187 GC patients and 56 healthy controls using real-time PCR. Immunohistochemical analysis using tissue microarrays was performed. RESULTS:UHRF1 DNA levels were significantly higher in GC patients compared to healthy controls (p < 0.001) and have associations with age and lymph node metastasis (LNM). The UHRF1 expression was significantly higher in tumor tissue than matched normal tissues (p < 0.001). CONCLUSIONS: The UHRF1 expression in serum and tissue may represent a novel biomarker for GC diagnosis and prognosis.
Authors: Hani Choudhry; Mazin A Zamzami; Ziad Omran; Wei Wu; Marc Mousli; Christian Bronner; Mahmoud Alhosin Journal: Oncol Lett Date: 2017-10-30 Impact factor: 2.967