P Subramaniam1, K Kumar1, K L Girish Babu1. 1. From the Department of Pedodontics and Preventive Dentistry The Oxford Dental College, Hospital and Research Centre, Hosur Road, Bommanahalli.
Abstract
UNLABELLED: Secretory IgA is the main type of immunoglobulin in saliva and is considered to be the main secretion factor of adaptive immunity in the mouth. OBJECTIVE: To assess the effect of Anti Retroviral Therapy on SIgA levels in saliva of HIV infected children. STUDY DESIGN: A cross-sectional sample of 50 HIV infected children aged 6-8 years were divided into 2 groups ; Group 1: children prior to onset of anti-retroviral therapy and Group 2: children undergoing anti-retroviral therapy. Stimulated whole saliva samples were collected from each child following I hour of breakfast. The samples were placed on ice packs and immediately transferred to a laboratory, processed and total SIgA quantification was estimated using ELISA. Data obtained was statistically analyzed. RESULTS: Among HIV infected children, significantly low SIgA levels of 6.2 mg/dl was seen in children prior to ART. CONCLUSION: Salivary IgA levels were significantly low in HIV infected children, particularly in children prior to ART.
UNLABELLED: Secretory IgA is the main type of immunoglobulin in saliva and is considered to be the main secretion factor of adaptive immunity in the mouth. OBJECTIVE: To assess the effect of Anti Retroviral Therapy on SIgA levels in saliva of HIV infectedchildren. STUDY DESIGN: A cross-sectional sample of 50 HIV infectedchildren aged 6-8 years were divided into 2 groups ; Group 1: children prior to onset of anti-retroviral therapy and Group 2: children undergoing anti-retroviral therapy. Stimulated whole saliva samples were collected from each child following I hour of breakfast. The samples were placed on ice packs and immediately transferred to a laboratory, processed and total SIgA quantification was estimated using ELISA. Data obtained was statistically analyzed. RESULTS: Among HIV infectedchildren, significantly low SIgA levels of 6.2 mg/dl was seen in children prior to ART. CONCLUSION: Salivary IgA levels were significantly low in HIV infectedchildren, particularly in children prior to ART.
Authors: Phoebe Pui Ying Lam; Ni Zhou; Hai Ming Wong; Cynthia Kar Yung Yiu Journal: Int J Environ Res Public Health Date: 2022-10-08 Impact factor: 4.614
Authors: Phoebe Pui Ying Lam; Ni Zhou; Cynthia Kar Yung Yiu; Hai Ming Wong Journal: Int J Environ Res Public Health Date: 2022-09-21 Impact factor: 4.614