Literature DB >> 26160550

Sarcoidosis-related hypercalcaemia due to production of parathyroid hormone-related peptide.

Daniel H van Raalte1, Susan M Goorden2, Evelien A Kemper3, Lodewijk A A Brosens4, Reinier W ten Kate1.   

Abstract

Hypercalcaemia is frequently observed in patients with sarcoidosis. This is classically attributed to ectopic production of 1,25 dihydroxy vitamin D by sarcoid granulomas. We present a case of sarcoidosis-related hypercalcaemia with normal vitamin D levels. In this patient, production of parathyroid hormone-related peptide (PTHrp) was the cause for sarcoidosis-induced hypercalcaemia. As such, plasma PTHrp levels were increased and bone marrow granulomas stained positively for PTHrp expression. Medium-dose prednisolone treatment improved symptoms of sarcoidosis and normalised serum calcium, and PTHrp concentrations. Thus, production of PTHrp may be the cause for hypercalcaemia in some patients with sarcoidosis. 2015 BMJ Publishing Group Ltd.

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Year:  2015        PMID： 26160550      PMCID： PMC4499713          DOI： 10.1136/bcr-2015-210189

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN： 1757-790X


  10 in total

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Authors:  J S Adams; F R Singer; M A Gacad; O P Sharma; M J Hayes; P Vouros; M F Holick
Journal:  J Clin Endocrinol Metab       Date:  1985-05       Impact factor: 5.958

5.  Parathyroid hormone-related protein: an unusual mechanism for hypercalcemia in sarcoidosis.

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6.  Continuous PTH and PTHrP infusion causes suppression of bone formation and discordant effects on 1,25(OH)2 vitamin D.

Authors:  Mara J Horwitz; Mary Beth Tedesco; Susan M Sereika; Mushtaq A Syed; Adolfo Garcia-Ocaña; Alessandro Bisello; Bruce W Hollis; Clifford J Rosen; John J Wysolmerski; Pamela Dann; Caren Gundberg; Andrew F Stewart
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4.  Intraoperative parathormone increase after focused parathyroidectomy in a patient with sarcoidosis - Case report.

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  4 in total

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