| Literature DB >> 26160452 |
Akiko Shitara1, Roberto Weigert2.
Abstract
In this mini-review we focus on the use of time-lapse light microscopy to study membrane remodeling during protein secretion in live animals. In particular, we highlight how subcellular intravital microscopy has enabled imaging the dynamics of both individual secretory vesicles and the plasma membrane, during different steps in the exocytic process. This powerful approach has provided us with the unique opportunity to unravel the role of the actin cytoskeleton in regulating this process under physiological conditions, and to overcome the shortcomings of more reductionist model systems. Published by Elsevier Inc.Entities:
Mesh：
Year: 2015 PMID： 26160452 PMCID： PMC4561585 DOI： 10.1016/j.yexcr.2015.06.018
Source DB: PubMed Journal: Exp Cell Res ISSN： 0014-4827 Impact factor: 3.905