Literature DB >> 2616037

Acetyl-L-carnitine enhances acetylcholine release in the striatum and hippocampus of awake freely moving rats.

A Imperato1, M T Ramacci, L Angelucci.   

Abstract

The effect of acetyl-L-carnitine (ALC) on the spontaneous release of acetylcholine (ACh) in the striatum and hippocampus of freely moving rats was investigated using brain microdialysis coupled with HPLC-electrochemical detection. Systemic administration of ALC, in a dose-dependent manner, stimulated ACh release in both areas, while the D-enantiomer was substantially ineffective. The effect of ALC was strongly Ca2+ dependent and tetrodotoxin (TTX) sensitive. These features of an exocytotic and impulse flow-dependent mechanism suggest that the increase in ACh release is the result of ALC activation of a physiological mechanism in cholinergic neurons.

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Year:  1989        PMID： 2616037     DOI： 10.1016/0304-3940(89)90826-4

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  18 in total

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4.  Acetyl-L-carnitine reduces impulsive behaviour in adolescent rats.

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Authors:  S Hudson; N Tabet
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