Mohammad Javad Zare Sakhvidi1, Javad Biabani Ardekani2, Ali Firoozichahak3, Javad Zavarreza4, Mohammad Hajaghazade5, Mehrdad Mostaghaci6, Amirhooshang Mehrparvar7, Abolfazl Barkhordari1. 1. Shahid Sadoughi University of Medical Sciences, Yazd, Iran (Faculty of Health, Department of Occupational Health). 2. Shahid Sadoughi University of Medical Sciences, Yazd, Iran (Food and Drug Laboratory). 3. Bam University of Medical Sciences, Kerman, Iran (Faculty of Health, Department of Occupational Health). 4. Shahid Sadoughi University of Medical Sciences, Yazd, Iran (Faculty of Medicine, Department of Clinical Biochemistry). 5. Urmia University of Medical Sciences, Urmia, Iran (Health Faculty, Department of Occupational Health). 6. Shahid Sadoughi University of Medical Sciences, Yazd, Iran (Faculty of Medicine, Department of Occupational Medicine). mehrdadmostaghaci@gmail.com. 7. Shahid Sadoughi University of Medical Sciences, Yazd, Iran (Faculty of Medicine, Department of Occupational Medicine).
Abstract
INTRODUCTION: The study aimed at measuring exhaled breath malondialdehyde (EBC-MDA) in workers exposed to dust containing silica and at its comparison with the non-exposed control group. MATERIAL AND METHODS: The cross sectional, case-control study (N = 50) was performed in a tile and ceramics production factory in Yazd, Iran. EBC-MDA was quantified in exhaled breath of the participants by a lab made breath sampler. Exposure intensity was measured according to the NIOSH 0600 method in selected homogeneous exposure groups. Additionally, spirometry test was conducted to investigate a correlation between EBC-MDA and spirometric findings in the exposed workers. RESULTS: There was no difference in the observed exposure intensities of silica containing dust in different units. However, "coating preparation" was the unit with the highest concentration of dust. Although, the level of EBC-MDA in the cases was slightly higher than in the controls, the difference was not statistically significant (U = 252, p = 0.464). A significant and positive correlation was found between dust exposure intensity in working units and the measured EBC-MDA of workers (r = 0.467, N = 25, p = 0.027). There were also no statistically significant differences among job categories in the exposed group for the values of FEV1% (F(3, 44) = 0.656, p = 0.584), FVC% (F(3, 44) = 1.417, p = 0.172), and FEV1/FVC% (F(3, 44) = 1.929, p = 0.139). CONCLUSIONS: The results showed a significant correlation between respirable dust exposure intensity and the level of EBC-MDA of the exposed subjects. However, our results did not show a significant correlation between lung function decreases and EBC-MDA. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.
INTRODUCTION: The study aimed at measuring exhaled breath malondialdehyde (EBC-MDA) in workers exposed to dust containing silica and at its comparison with the non-exposed control group. MATERIAL AND METHODS: The cross sectional, case-control study (N = 50) was performed in a tile and ceramics production factory in Yazd, Iran. EBC-MDA was quantified in exhaled breath of the participants by a lab made breath sampler. Exposure intensity was measured according to the NIOSH 0600 method in selected homogeneous exposure groups. Additionally, spirometry test was conducted to investigate a correlation between EBC-MDA and spirometric findings in the exposed workers. RESULTS: There was no difference in the observed exposure intensities of silica containing dust in different units. However, "coating preparation" was the unit with the highest concentration of dust. Although, the level of EBC-MDA in the cases was slightly higher than in the controls, the difference was not statistically significant (U = 252, p = 0.464). A significant and positive correlation was found between dust exposure intensity in working units and the measured EBC-MDA of workers (r = 0.467, N = 25, p = 0.027). There were also no statistically significant differences among job categories in the exposed group for the values of FEV1% (F(3, 44) = 0.656, p = 0.584), FVC% (F(3, 44) = 1.417, p = 0.172), and FEV1/FVC% (F(3, 44) = 1.929, p = 0.139). CONCLUSIONS: The results showed a significant correlation between respirable dust exposure intensity and the level of EBC-MDA of the exposed subjects. However, our results did not show a significant correlation between lung function decreases and EBC-MDA. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.
Authors: Anjoeka Pronk; Miranda Loh; Eelco Kuijpers; Maria Albin; Jenny Selander; Lode Godderis; Manosij Ghosh; Roel Vermeulen; Susan Peters; Ingrid Sivesind Mehlum; Michelle C Turner; Vivi Schlünssen; Marcel Goldberg; Manolis Kogevinas; Barbara N Harding; Svetlana Solovieva; Tina Garani-Papadatos; Martie van Tongeren; Rob Stierum Journal: Environ Epidemiol Date: 2022-02-17