Metabolic reprogramming as a continuous changing behavior of tumor cells.

Malignant cells resist microenvironment stress and migrate into surrounding tissues in order to divide with the need to adapt their metabolic program. These changes, often strengthened by the tremendous liaison between hypoxia, low glucose, and acidosis, are not yet completely understood. The aim of this perspective is to re-organize a possible comprehensive scenario useful to identify the metabolism occurring in various tumor cell subpopulations endowed with different capabilities.