Literature DB >> 26159714

Bacterial Reductionism: Host Thiols Enhance Virulence.

Vanessa Sperandio1.   

Abstract

Intracellular bacteria exploit host cytosolic signals to upregulate virulence genes. In this issue of Cell Host & Microbe, Wong et al. (2015) show that Burkholderia pseudomallei senses host cytosolic glutathione, a low-molecular-weight thiol, through the membrane-bound histidine sensor kinase VirA, highlighting the importance of inter-kingdom signaling in bacterial pathogenesis.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 26159714      PMCID： PMC5072125          DOI： 10.1016/j.chom.2015.06.010

Source DB:  PubMed          Journal:  Cell Host Microbe        ISSN： 1931-3128            Impact factor:   21.023


  11 in total

Review 1.  Glutathione metabolism and its implications for health.

Authors:  Guoyao Wu; Yun-Zhong Fang; Sheng Yang; Joanne R Lupton; Nancy D Turner
Journal:  J Nutr       Date:  2004-03       Impact factor: 4.798

Review 2.  Inter-kingdom signalling: communication between bacteria and their hosts.

Authors:  David T Hughes; Vanessa Sperandio
Journal:  Nat Rev Microbiol       Date:  2008-02       Impact factor: 60.633

3.  Regulation of type VI secretion system during Burkholderia pseudomallei infection.

Authors:  Yahua Chen; Jocelyn Wong; Guang Wen Sun; Yichun Liu; Gek-Yen Gladys Tan; Yunn-Hwen Gan
Journal:  Infect Immun       Date:  2011-06-13       Impact factor: 3.441

4.  Glutathione activates virulence gene expression of an intracellular pathogen.

Authors:  Michelle L Reniere; Aaron T Whiteley; Keri L Hamilton; Sonya M John; Peter Lauer; Richard G Brennan; Daniel A Portnoy
Journal:  Nature       Date:  2015-01-08       Impact factor: 49.962

Review 5.  Molecular insights into Burkholderia pseudomallei and Burkholderia mallei pathogenesis.

Authors:  Edouard E Galyov; Paul J Brett; David DeShazer
Journal:  Annu Rev Microbiol       Date:  2010       Impact factor: 15.500

Review 6.  Glutathione and its role in cellular functions.

Authors:  H Sies
Journal:  Free Radic Biol Med       Date:  1999-11       Impact factor: 7.376

7.  Host Cytosolic Glutathione Sensing by a Membrane Histidine Kinase Activates the Type VI Secretion System in an Intracellular Bacterium.

Authors:  Jocelyn Wong; Yahua Chen; Yunn-Hwen Gan
Journal:  Cell Host Microbe       Date:  2015-06-18       Impact factor: 21.023

8.  Identification of Burkholderia pseudomallei genes required for the intracellular life cycle and in vivo virulence.

Authors:  Sabine Pilatz; Katrin Breitbach; Nadine Hein; Beate Fehlhaber; Jessika Schulze; Birgit Brenneke; Leo Eberl; Ivo Steinmetz
Journal:  Infect Immun       Date:  2006-06       Impact factor: 3.441

9.  The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei.

Authors:  Mary N Burtnick; Paul J Brett; Sarah V Harding; Sarah A Ngugi; Wilson J Ribot; Narisara Chantratita; Angelo Scorpio; Timothy S Milne; Rachel E Dean; David L Fritz; Sharon J Peacock; Joanne L Prior; Timothy P Atkins; David Deshazer
Journal:  Infect Immun       Date:  2011-02-07       Impact factor: 3.441

Review 10.  Listeria monocytogenes - from saprophyte to intracellular pathogen.

Authors:  Nancy E Freitag; Gary C Port; Maurine D Miner
Journal:  Nat Rev Microbiol       Date:  2009-08-03       Impact factor: 60.633
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  1 in total

1.  Two stable variants of Burkholderia pseudomallei strain MSHR5848 express broadly divergent in vitro phenotypes associated with their virulence differences.

Authors:  A A Shea; R C Bernhards; C K Cote; C J Chase; J W Koehler; C P Klimko; J T Ladner; D A Rozak; M J Wolcott; D P Fetterer; S J Kern; G I Koroleva; S P Lovett; G F Palacios; R G Toothman; J A Bozue; P L Worsham; S L Welkos
Journal:  PLoS One       Date:  2017-02-10       Impact factor: 3.240
  1 in total

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