BACKGROUND: Sleep disturbances and disruption of the neural regulation of the sleep-wake rhythm appear to be involved in the cellular and molecular mechanisms of cognitive decline. Although sleep problems are highly prevalent in mild cognitive impairment (MCI) and many types of dementia, they have not been systematically investigated in the clinical setting and are often only investigated by sleep specialists upon individual request. SUMMARY: This review discusses sleep disorders in the context of cognitive decline and provides an overview of the clinical diagnosis and management of these disorders in patients with dementia and MCI. Key Messages: Sleep disorders are largely underestimated and do not receive sufficient attention in the global management of dementia patients. Sleep disturbances have a significant impact on cognitive and physical functions in individuals with cognitive decline and may be associated with important psychological distress and depression. They are positively associated with the severity of behavioral problems and cognitive impairment. CLINICAL IMPLICATIONS: The recent recommendations by the Sleep Study Group of the Italian Dementia Research Association can be used as a guideline for the clinical assessment and management of sleep disorders in MCI and dementia patients. Sleep disorders should be carefully investigated using an in-depth sleep history, physical examination, questionnaires and clinical scales and should be validated with the support of a direct caregiver. The recommendations for older adults can be used as a framework to guide the diagnosis and treatment of sleep disorders in individuals with dementia and MCI. The management strategy should be based on the choice of different treatments for each sleep problem present in the same patient, while avoiding adverse interactions between treatments.
BACKGROUND: Sleep disturbances and disruption of the neural regulation of the sleep-wake rhythm appear to be involved in the cellular and molecular mechanisms of cognitive decline. Although sleep problems are highly prevalent in mild cognitive impairment (MCI) and many types of dementia, they have not been systematically investigated in the clinical setting and are often only investigated by sleep specialists upon individual request. SUMMARY: This review discusses sleep disorders in the context of cognitive decline and provides an overview of the clinical diagnosis and management of these disorders in patients with dementia and MCI. Key Messages: Sleep disorders are largely underestimated and do not receive sufficient attention in the global management of dementiapatients. Sleep disturbances have a significant impact on cognitive and physical functions in individuals with cognitive decline and may be associated with important psychological distress and depression. They are positively associated with the severity of behavioral problems and cognitive impairment. CLINICAL IMPLICATIONS: The recent recommendations by the Sleep Study Group of the Italian Dementia Research Association can be used as a guideline for the clinical assessment and management of sleep disorders in MCI and dementiapatients. Sleep disorders should be carefully investigated using an in-depth sleep history, physical examination, questionnaires and clinical scales and should be validated with the support of a direct caregiver. The recommendations for older adults can be used as a framework to guide the diagnosis and treatment of sleep disorders in individuals with dementia and MCI. The management strategy should be based on the choice of different treatments for each sleep problem present in the same patient, while avoiding adverse interactions between treatments.
Authors: Brittany Rohl; Kathleen Collins; Sarah Morgan; Stephanie Cosentino; Edward D Huey; Elan D Louis Journal: J Neurol Sci Date: 2016-10-08 Impact factor: 3.181
Authors: M J Duncan; L E Guerriero; K Kohler; L E Beechem; B D Gillis; F Salisbury; C Wessel; J Wang; S Sunderam; A D Bachstetter; B F O'Hara; M P Murphy Journal: Neuroscience Date: 2021-11-29 Impact factor: 3.590
Authors: Salvatore Campanella; Kemal Arikan; Claudio Babiloni; Michela Balconi; Maurizio Bertollo; Viviana Betti; Luigi Bianchi; Martin Brunovsky; Carla Buttinelli; Silvia Comani; Giorgio Di Lorenzo; Daniel Dumalin; Carles Escera; Andreas Fallgatter; Derek Fisher; Giulia Maria Giordano; Bahar Guntekin; Claudio Imperatori; Ryouhei Ishii; Hendrik Kajosch; Michael Kiang; Eduardo López-Caneda; Pascal Missonnier; Armida Mucci; Sebastian Olbrich; Georges Otte; Andrea Perrottelli; Alessandra Pizzuti; Diego Pinal; Dean Salisbury; Yingying Tang; Paolo Tisei; Jijun Wang; Istvan Winkler; Jiajin Yuan; Oliver Pogarell Journal: Clin EEG Neurosci Date: 2020-09-25 Impact factor: 1.843