Schizophrenia.

Theoretical conceptualizations of schizophrenia have undergone significant change in the past century. Through the application of behavioral science methodology, psychologists have played a major role in the pivotal scientific advances that have led us to contemporary models. The field has moved from simplistic conceptualizations of mind-brain distinctions to models that encompass complex gene-environment interactions and neural pathways that mediate the relation between psychosocial events and brain dysfunction.