Literature DB >> 2615791

A versiconal hemiacetal acetate converting enzyme in aflatoxin biosynthesis.

D P Hsieh1, C C Wan, J A Billington.   

Abstract

Conversion of the aflatoxin biosynthetic intermediate versiconal hemiacetal acetate (VHA) in a cell free extract of Aspergillus parasiticus ATCC 15517 is investigated. The enzymatic reaction is monitored by a method using high performance liquid chromatography (HPLC). The major product of the enzymatic reaction is a water soluble compound not chloroform-extractable at pH 7.5. The product becomes chloroform extractable upon acidification of the reaction medium and is separated and quantitated by reversed-phase HPLC. It is tentatively identified as 'versiconal hemiacetal alcohol,' which is converted to versicolorin C (VC) upon acid treatment.

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Year:  1989        PMID： 2615791     DOI： 10.1007/bf00707548

Source DB:  PubMed          Journal:  Mycopathologia        ISSN： 0301-486X            Impact factor:   2.574


  9 in total

1.  INCORPORATION OF LABELLED COMPOUNDS INTO AFLATOXINS.

Authors:  J ADYE; R I MATELES
Journal:  Biochim Biophys Acta       Date:  1964-05-11

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Authors:  D G Kingston; P N Chen
Journal:  J Chromatogr       Date:  1976-04-07

3.  Nuclear magnetic resonance identification of versiconal hemiacetal acetate as an intermediate in aflatoxin biosynthesis.

Authors:  D L Fitzell; R Singh; D P Hsieh; E L Motell
Journal:  J Agric Food Chem       Date:  1977 Sep-Oct       Impact factor: 5.279

4.  Appearance of enzyme activities catalyzing conversion of sterigmatocystin to aflatoxin B1 in late-growth-phase Aspergillus parasiticus cultures.

Authors:  T E Cleveland; A R Lax; L S Lee; D Bhatnagar
Journal:  Appl Environ Microbiol       Date:  1987-07       Impact factor: 4.792

5.  Identification of O-methylsterigmatocystin as an aflatoxin B1 and G1 precursor in Aspergillus parasiticus.

Authors:  D Bhatnagar; S P McCormick; L S Lee; R A Hill
Journal:  Appl Environ Microbiol       Date:  1987-05       Impact factor: 4.792

6.  Mutagenicity of aflatoxins related to their metabolism and carcinogenic potential.

Authors:  J J Wong; D P Hsieh
Journal:  Proc Natl Acad Sci U S A       Date:  1976-07       Impact factor: 11.205

7.  Step of dichlorvos inhibition in the pathway of aflatoxin biosynthesis.

Authors:  R C Yao; D P Hsieh
Journal:  Appl Microbiol       Date:  1974-07

8.  Enzymatic formation of the bisfuran structure in aflatoxin biosynthesis.

Authors:  N C Wan; D P Hsieh
Journal:  Appl Environ Microbiol       Date:  1980-01       Impact factor: 4.792

9.  Inhibition of aflatoxin production and tentative identification of an aflatoxin intermediate "versiconal acetate" from treatment with dichlorvos.

Authors:  H W Schroeder; R J Cole; R D Grigsby; H Hein
Journal:  Appl Microbiol       Date:  1974-02
  9 in total
  16 in total

Review 1.  Clustered pathway genes in aflatoxin biosynthesis.

Authors:  Jiujiang Yu; Perng-Kuang Chang; Kenneth C Ehrlich; Jeffrey W Cary; Deepak Bhatnagar; Thomas E Cleveland; Gary A Payne; John E Linz; Charles P Woloshuk; Joan W Bennett
Journal:  Appl Environ Microbiol       Date:  2004-03       Impact factor: 4.792

2.  Purification and characterization of two versiconal hemiacetal acetate reductases involved in aflatoxin biosynthesis.

Authors:  K Matsushima; Y Ando; T Hamasaki; K Yabe
Journal:  Appl Environ Microbiol       Date:  1994-07       Impact factor: 4.792

3.  Enzymes in aflatoxin biosynthesis.

Authors:  J A Anderson
Journal:  World J Microbiol Biotechnol       Date:  1992-12       Impact factor: 3.312

4.  Molecular characterization of the afl-1 locus in Aspergillus flavus.

Authors:  C P Woloshuk; G L Yousibova; J A Rollins; D Bhatnagar; G A Payne
Journal:  Appl Environ Microbiol       Date:  1995-08       Impact factor: 4.792

5.  Purification of a 40-kilodalton methyltransferase active in the aflatoxin biosynthetic pathway.

Authors:  N P Keller; H C Dischinger; D Bhatnagar; T E Cleveland; A H Ullah
Journal:  Appl Environ Microbiol       Date:  1993-02       Impact factor: 4.792

6.  Stereochemistry during aflatoxin biosynthesis: cyclase reaction in the conversion of versiconal to versicolorin B and racemization of versiconal hemiacetal acetate.

Authors:  K Yabe; T Hamasaki
Journal:  Appl Environ Microbiol       Date:  1993-08       Impact factor: 4.792

7.  Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans.

Authors:  D W Brown; J H Yu; H S Kelkar; M Fernandes; T C Nesbitt; N P Keller; T H Adams; T J Leonard
Journal:  Proc Natl Acad Sci U S A       Date:  1996-02-20       Impact factor: 11.205

8.  Isolation and characterization of a gene from Aspergillus parasiticus associated with the conversion of versicolorin A to sterigmatocystin in aflatoxin biosynthesis.

Authors:  C D Skory; P K Chang; J Cary; J E Linz
Journal:  Appl Environ Microbiol       Date:  1992-11       Impact factor: 4.792

9.  Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin.

Authors:  K Yabe; Y Matsuyama; Y Ando; H Nakajima; T Hamasaki
Journal:  Appl Environ Microbiol       Date:  1993-08       Impact factor: 4.792

10.  Cloning and functional expression of an esterase gene in Aspergillus parasitcus.

Authors:  Jiujiang Yu; Perng-Kuang Chang; Deepak Bhatnagar; Thomas E Cleveland
Journal:  Mycopathologia       Date:  2002       Impact factor: 2.574
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