Literature DB >> 2615776

Age-related methylation changes in DNA may reflect the proliferative potential of organs.

E G Hoal-van Helden1, P D van Helden.   

Abstract

The percentage of 5-methylcytosine in DNA was measured in brain, liver, heart and skeletal muscle of the rat at various ages. Age-related hypomethylation occurred rapidly shortly after birth and then declined to eventually stabilize in brain, heart and skeletal muscle. Hypomethylation in liver DNA continued throughout the period studied (6 months). Our hypothesis that the age-related decline of 5-methylcytosine content in DNA is related to the proliferative potential of organs is discussed.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2615776     DOI： 10.1016/0921-8734(89)90027-1

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  11 in total

1.  Predicting Chronological Age from DNA Methylation Data: A Machine Learning Approach for Small Datasets and Limited Predictors.

Authors:  Anastasia Aliferi; David Ballard
Journal:  Methods Mol Biol       Date:  2022

2.  Stable knockdown of PASG enhances DNA demethylation but does not accelerate cellular senescence in TIG-7 human fibroblasts.

Authors:  Toshikazu Suzuki; Jason E Farrar; Srinivasan Yegnasubramanian; Muhammed Zahed; Nobuo Suzuki; Robert J Arceci
Journal:  Epigenetics       Date:  2008-09-03       Impact factor: 4.528

3.  Decline in genomic DNA methylation through aging in a cohort of elderly subjects.

Authors:  Valentina Bollati; Joel Schwartz; Robert Wright; Augusto Litonjua; Letizia Tarantini; Helen Suh; David Sparrow; Pantel Vokonas; Andrea Baccarelli
Journal:  Mech Ageing Dev       Date:  2008-12-27       Impact factor: 5.432

Review 4.  Epigenetics and Human Disease.

Authors:  Huda Y Zoghbi; Arthur L Beaudet
Journal:  Cold Spring Harb Perspect Biol       Date:  2016-02-01       Impact factor: 10.005

5.  Somatic DNA Hypomethylation in H. pylori-Associated High-Risk Gastritis and Gastric Cancer: Enhanced Somatic Hypomethylation Associates with Advanced Stage Cancer.

Authors:  Andreas Leodolter; Sergio Alonso; Beatriz González; Matthias P Ebert; Michael Vieth; Christoph Röcken; Thomas Wex; Ullrich Peitz; Peter Malfertheiner; Manuel Perucho
Journal:  Clin Transl Gastroenterol       Date:  2015-04-30       Impact factor: 4.488

6.  The Association of LINE-1 Hypomethylation with Age and Centromere Positive Micronuclei in Human Lymphocytes.

Authors:  Yoon Hee Cho; Hae Dong Woo; Yoonhee Jang; Virginia Porter; Sonja Christensen; Raymond F Hamilton; Hai Won Chung
Journal:  PLoS One       Date:  2015-07-21       Impact factor: 3.240

7.  Predictors and consequences of global DNA methylation in cord blood and at three years.

Authors:  Julie B Herbstman; Shuang Wang; Frederica P Perera; Sally A Lederman; Julia Vishnevetsky; Andrew G Rundle; Lori A Hoepner; Lirong Qu; Deliang Tang
Journal:  PLoS One       Date:  2013-09-04       Impact factor: 3.240

8.  Nuclear DNA methylation and chromatin condensation phenotypes are distinct between normally proliferating/aging, rapidly growing/immortal, and senescent cells.

Authors:  Jin Ho Oh; Arkadiusz Gertych; Jian Tajbakhsh
Journal:  Oncotarget       Date:  2013-03

Review 9.  Dynamic Alu methylation during normal development, aging, and tumorigenesis.

Authors:  Yanting Luo; Xuemei Lu; Hehuang Xie
Journal:  Biomed Res Int       Date:  2014-08-27       Impact factor: 3.411

10.  Epigenomic Indicators of Age in African Americans.

Authors:  Jennifer A Smith; Alicia L Zagel; Yan V Sun; Dana C Dolinoy; Lawrence F Bielak; Patricia A Peyser; Stephen T Turner; Thomas H Mosley; Sharon Lr Kardia
Journal:  Hereditary Genet       Date:  2014-10-01
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.