Literature DB >> 2615625

Monoclonal antibody-coated magnetite particles as contrast agents in magnetic resonance imaging of tumors.

S Cerdan1, H R Lötscher, B Künnecke, J Seelig.   

Abstract

A highly specific and powerful magnetic resonance imaging contrast agent has been prepared by coating magnetite (Fe3O4) particles with monoclonal antibodies directed against a tumor antigen. The preparation maintains both the immunoreactivity of the monoclonal antibody and the full relaxing capability of the magnetite particle. MRI image contrast by spin-echo methods can be easily induced in a concentration range of 1-10 nM of the antibody-coated magnetite particles.

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Year:  1989        PMID： 2615625     DOI： 10.1002/mrm.1910120202

Source DB:  PubMed          Journal:  Magn Reson Med        ISSN： 0740-3194            Impact factor:   4.668


  7 in total

Review 1.  Magnetic nanoparticles in MR imaging and drug delivery.

Authors:  Conroy Sun; Jerry S H Lee; Miqin Zhang
Journal:  Adv Drug Deliv Rev       Date:  2008-04-10       Impact factor: 15.470

2.  Targeted signal-amplifying enzymes enhance MRI of EGFR expression in an orthotopic model of human glioma.

Authors:  Mohammed S Shazeeb; Christopher H Sotak; Michael DeLeo; Alexei Bogdanov
Journal:  Cancer Res       Date:  2011-01-18       Impact factor: 12.701

3.  Sensitive and automated detection of iron-oxide-labeled cells using phase image cross-correlation analysis.

Authors:  Parker H Mills; Yi-Jen L Wu; Chien Ho; Eric T Ahrens
Journal:  Magn Reson Imaging       Date:  2008-05-02       Impact factor: 2.546

Review 4.  Metalloprotein-based MRI probes.

Authors:  Yuri Matsumoto; Alan Jasanoff
Journal:  FEBS Lett       Date:  2013-01-31       Impact factor: 4.124

5.  Specific targeting of folate-dendrimer MRI contrast agents to the high affinity folate receptor expressed in ovarian tumor xenografts.

Authors:  S D Konda; M Aref; S Wang; M Brechbiel; E C Wiener
Journal:  MAGMA       Date:  2001-05       Impact factor: 2.533

6.  Biocompatibility of very small superparamagnetic iron oxide nanoparticles in murine organotypic hippocampal slice cultures and the role of microglia.

Authors:  Martin Pohland; Robert Glumm; Frank Wiekhorst; Jürgen Kiwit; Jana Glumm
Journal:  Int J Nanomedicine       Date:  2017-02-27

Review 7.  Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy.

Authors:  Xiang-Hong Peng; Ximei Qian; Hui Mao; Andrew Y Wang; Zhuo Georgia Chen; Shuming Nie; Dong M Shin
Journal:  Int J Nanomedicine       Date:  2008
  7 in total

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