X-Q Ding1, H Lanfermann1. 1. Institute of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. ding.xiaoqi@mh-hannover.de.
Abstract
OBJECTIVE: Accompanying the advance of neuroscientific research and modern therapeutic methods, efforts have been made to develop more practical and effective advanced magnetic resonance (MR) spectroscopic techniques. METHODS: We present a brief overview on (1)H-MRS techniques in neuroradiological diagnosis and several application examples of recently reported whole brain MR spectroscopic imaging technique (wbMRSI). RESULTS: Despite the benefits of using established (1)H-MRS techniques both single voxel MR spectroscopy (SVS) and chemical shift imaging (CSI) techniques suffer from limited spatial coverage. It is always necessary to define prior to the MRS examination which brain structure is physiologically or pathologically involved and thus should be targeted with (1)H-MRS. In contrast, the advanced wbMRSI allows estimating metabolite changes within a much larger brain region and at multiple brain structures simultaneously. CONCLUSIONS: As a developing technique for advanced analysis of cerebral metabolism a wide application of the wbMRSI in both clinical diagnostics and neuroscience could be expected.
OBJECTIVE: Accompanying the advance of neuroscientific research and modern therapeutic methods, efforts have been made to develop more practical and effective advanced magnetic resonance (MR) spectroscopic techniques. METHODS: We present a brief overview on (1)H-MRS techniques in neuroradiological diagnosis and several application examples of recently reported whole brain MR spectroscopic imaging technique (wbMRSI). RESULTS: Despite the benefits of using established (1)H-MRS techniques both single voxel MR spectroscopy (SVS) and chemical shift imaging (CSI) techniques suffer from limited spatial coverage. It is always necessary to define prior to the MRS examination which brain structure is physiologically or pathologically involved and thus should be targeted with (1)H-MRS. In contrast, the advanced wbMRSI allows estimating metabolite changes within a much larger brain region and at multiple brain structures simultaneously. CONCLUSIONS: As a developing technique for advanced analysis of cerebral metabolism a wide application of the wbMRSI in both clinical diagnostics and neuroscience could be expected.
Entities:
Keywords:
Brain metabolite; Chemical shift imaging; Single voxel spectroscopy; Whole brain MR spectroscopic imaging
Authors: Ulrich Pilatus; Christoph Lais; Anna du Mesnil de Rochmont; Tillmann Kratzsch; Lutz Frölich; Konrad Maurer; Friedhelm E Zanella; Heinrich Lanfermann; Johannes Pantel Journal: Psychiatry Res Date: 2009-05-09 Impact factor: 3.222
Authors: Thomas Alderliesten; Linda S de Vries; Manon J N L Benders; Corine Koopman; Floris Groenendaal Journal: Radiology Date: 2011-08-09 Impact factor: 11.105
Authors: Elvis J Hermann; Elke Hattingen; Joachim K Krauss; Gerhard Marquardt; Ulrich Pilatus; Kea Franz; Matthias Setzer; Thomas Gasser; Dominique S Tews; Friedhelm E Zanella; Volker Seifert; Heinrich Lanfermann Journal: Stereotact Funct Neurosurg Date: 2008-09-15 Impact factor: 1.875
Authors: Varan Govind; Khema R Sharma; Andrew A Maudsley; Kristopher L Arheart; Gaurav Saigal; Sulaiman Sheriff Journal: PLoS One Date: 2012-04-23 Impact factor: 3.240
Authors: Yue Zhang; Edward Taub; Nouha Salibi; Gitendra Uswatte; Andrew A Maudsley; Sulaiman Sheriff; Brent Womble; Victor W Mark; David C Knight Journal: NMR Biomed Date: 2018-02-13 Impact factor: 4.044
Authors: Helen Maghsudi; Birte Schmitz; Andrew A Maudsley; Sulaiman Sheriff; Paul Bronzlik; Martin Schütze; Heinrich Lanfermann; Xiaoqi Ding Journal: Clin Neuroradiol Date: 2019-01-18 Impact factor: 3.649