| Literature DB >> 26155736 |
Dhanasekaran Bodhini1, Manickam Chidambaram1,2, Samuel Liju1, Visvanathan G Prakash1, Vijay Gayathri1, Coimbatore S Shanthirani1, Unnikrishnan Ranjith3, Ranjit M Anjana1,3, Viswanathan Mohan1,3, Venkatesan Radha1.
Abstract
The transcription factor 7-like 2 (TCF7L2) gene plays a significant role in the development of type 2 diabetes and diabetic nephropathy. The aim of this study was to investigate the association of TCF7L2 rs12255372 (G/T)polymorphism with type 2 diabetic nephropathy in the South Indian population. A total of 2102 subjects, 927 normal glucose tolerant (NGT) subjects, 598 type 2 diabetic subjects without nephropathy (DM), and 577 type 2 diabetic subjects with nephropathy (DN) were genotyped by MassARRAY. As compared to the NGT group, the odds ratio (adjusted for age, sex, BMI, HbA1c, and systolic BP) computed for the GT/TT genotype taking the GG genotype as reference was found to be 2.02 (95% CI: 1.16-3.51, p = 0.013) for DN and 1.94 (95% CI: 1.36-2.78, p = 0.0002) for DM. The genotype frequency was not significantly different between the DM and DN groups. In conclusion, the rs12255372 polymorphism in the TCF7L2 gene is associated with type 2 diabetes and DN but its association with DN is mediated through diabetes.Entities:
Keywords: TCF7L2 gene; diabetic nephropathy; rs12255372 variant; south Indians; type 2 diabetes
Year: 2015 PMID： 26155736 DOI： 10.1111/ahg.12122
Source DB: PubMed Journal: Ann Hum Genet ISSN： 0003-4800 Impact factor: 1.670