Literature DB >> 26155398

Time to Akt: Superior tumor-reactive T cells for adoptive immunotherapy.

Anniek B van der Waart1, Willemijn Hobo1, Harry Dolstra1.   

Abstract

T cells are crucial players in the protection against cancer, and can be used in adoptive cell therapy to prevent or treat relapse. However, their state of differentiation determines their effectiveness, with early memory cells being the most favorable. Here, we discuss restraining of differentiation to engineer the ultimate tumor-reactive T cell.

Entities:  

Keywords:  ACT: adoptive cell therapy; APC: antigen-presenting cells; Akt; Allo-SCT: allogeneic stem cell transplantation; CAR: chimeric antigen receptor; DCs: dendritic cells; IL-15; IL-7; MiHAs: minor histocompatibility antigens; T-cell differentiation; TCR: T-cell receptor; TILs: tumor-infiltrating lymphocytes; Tcm: central memory T; Teff: effector T; Tem: effector memory T; Tn: naive T; Tscm: stem cell memory T; Wnt; adoptive T cell therapy; dendritic cell; stem cell transplantation

Year:  2015        PMID： 26155398      PMCID： PMC4485741          DOI： 10.1080/2162402X.2014.1003016

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

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Authors:  Christian Stemberger; Michael Neuenhahn; Friedemann E Gebhardt; Matthias Schiemann; Veit R Buchholz; Dirk H Busch
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5.  Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy.

Authors:  Anniek B van der Waart; Noortje M P van de Weem; Frans Maas; Cynthia S M Kramer; Michel G D Kester; J H Frederik Falkenburg; Nicolaas Schaap; Joop H Jansen; Robbert van der Voort; Luca Gattinoni; Willemijn Hobo; Harry Dolstra
Journal:  Blood       Date:  2014-10-21       Impact factor: 22.113

6.  Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.

Authors:  Joseph G Crompton; Madhusudhanan Sukumar; Rahul Roychoudhuri; David Clever; Alena Gros; Robert L Eil; Eric Tran; Ken-Ichi Hanada; Zhiya Yu; Douglas C Palmer; Sid P Kerkar; Ryan D Michalek; Trevor Upham; Anthony Leonardi; Nicolas Acquavella; Ena Wang; Francesco M Marincola; Luca Gattinoni; Pawel Muranski; Mark S Sundrud; Christopher A Klebanoff; Steven A Rosenberg; Douglas T Fearon; Nicholas P Restifo
Journal:  Cancer Res       Date:  2014-11-28       Impact factor: 12.701

Review 7.  Sorting through subsets: which T-cell populations mediate highly effective adoptive immunotherapy?

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Journal:  Nat Med       Date:  2011-09-18       Impact factor: 53.440
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  2 in total

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