| Literature DB >> 26154788 |
Bernd Hoffmann1, Dennis Tappe, Dirk Höper, Christiane Herden, Annemarie Boldt, Christian Mawrin, Olaf Niederstraßer, Tobias Müller, Maria Jenckel, Elisabeth van der Grinten, Christian Lutter, Björn Abendroth, Jens P Teifke, Daniel Cadar, Jonas Schmidt-Chanasit, Rainer G Ulrich, Martin Beer.
Abstract
Between 2011 and 2013, three breeders of variegated squirrels (Sciurus variegatoides) had encephalitis with similar clinical signs and died 2 to 4 months after onset of the clinical symptoms. With the use of a metagenomic approach that incorporated next-generation sequencing and real-time reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR), the presence of a previously unknown bornavirus was detected in a contact squirrel and in brain samples from the three patients. Phylogenetic analyses showed that this virus, tentatively named variegated squirrel 1 bornavirus (VSBV-1), forms a lineage separate from that of the known bornavirus species. (Funded by the Federal Ministry of Food and Agriculture [Germany] and others.).Entities:
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Year: 2015 PMID： 26154788 DOI： 10.1056/NEJMoa1415627
Source DB: PubMed Journal: N Engl J Med ISSN： 0028-4793 Impact factor: 91.245