Literature DB >> 26154613

Expedient and Divergent Tandem One-Pot Synthesis of Benz[e]indole and Spiro[indene-1,3'-pyrrole] Derivatives from Alkyne-Tethered Chalcones/Cinnamates and TosMIC.

Xue Zhang1, Chengjie Feng1, Tao Jiang2, Yifei Li1, Ling Pan1, Xianxiu Xu1.   

Abstract

An efficient solvent-dependent regioselective [3 + 2]-cycloaddition/iodocyclization cascade reaction of alkyne-tethered chalcones/cinnamates and TosMIC has been developed. The reaction represents a novel protocol for the expedient and divergent one-pot synthesis of benz[e]indoles and spiro[indene-1,3'-pyrroles] from acyclic common precursors at room temperature.

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Year:  2015        PMID： 26154613     DOI： 10.1021/acs.orglett.5b01676

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  [3+2] Cycloaddition of Tosylmethyl Isocyanide with Styrylisoxazoles: Facile Access to Polysubstituted 3-(Isoxazol-5-yl)pyrroles.

Authors:  Xueming Zhang; Xianxiu Xu; Dawei Zhang
Journal:  Molecules       Date:  2017-07-07       Impact factor: 4.411

Review 2.  Synthesis of Multi-Substituted Pyrrole Derivatives Through [3+2] Cycloaddition with Tosylmethyl Isocyanides (TosMICs) and Electron-Deficient Compounds.

Authors:  Zhengning Ma; Zicheng Ma; Dawei Zhang
Journal:  Molecules       Date:  2018-10-17       Impact factor: 4.411
  2 in total

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