CONTEXT: Chromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis. OBJECTIVE: Assess association of CgA levels and mortality risk of severely septic patients. METHODS: Serum CgA levels were measured in 50 hospitalized, severely septic patients with organ failure <48 h. RESULTS: Higher CgA levels trended toward higher ICU and hospital mortality. Patients without cardiovascular disease who died in the ICU had higher median (IQR) CgA levels 602.3 (343.3, 1134.3) ng/ml versus 205.5 (130.7, 325.9) ng/ml, p = 0.01. CONCLUSIONS: High CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.
CONTEXT: Chromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis. OBJECTIVE: Assess association of CgA levels and mortality risk of severely septic patients. METHODS: Serum CgA levels were measured in 50 hospitalized, severely septic patients with organ failure <48 h. RESULTS: Higher CgA levels trended toward higher ICU and hospital mortality. Patients without cardiovascular disease who died in the ICU had higher median (IQR) CgA levels 602.3 (343.3, 1134.3) ng/ml versus 205.5 (130.7, 325.9) ng/ml, p = 0.01. CONCLUSIONS: High CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.
Authors: Djillali Annane; Philippe Aegerter; Marie Claude Jars-Guincestre; Bertrand Guidet Journal: Am J Respir Crit Care Med Date: 2003-07-15 Impact factor: 21.405
Authors: Eric M Mortensen; Ethan A Halm; Mary Jo Pugh; Laurel A Copeland; Mark Metersky; Michael J Fine; Christopher S Johnson; Carlos A Alvarez; Christopher R Frei; Chester Good; Marcos I Restrepo; John R Downs; Antonio Anzueto Journal: JAMA Date: 2014-06-04 Impact factor: 56.272
Authors: Bravein Amalakuhan; Sheila A Habib; Mandeep Mangat; Luis F Reyes; Alejandro H Rodriguez; Cecilia A Hinojosa; Nilam J Soni; Ryan P Gilley; Carlos A Bustamante; Antonio Anzueto; Stephanie M Levine; Jay I Peters; Stefano Aliberti; Oriol Sibila; James D Chalmers; Antoni Torres; Grant W Waterer; Ignacio Martin-Loeches; Jose Bordon; Jose Blanquer; Francisco Sanz; Pedro J Marcos; Jordi Rello; Julio Ramirez; Jordi Solé-Violán; Carlos M Luna; Charles Feldman; Martin Witzenrath; Richard G Wunderink; Daiana Stolz; Tim L Wiemken; Yuichiro Shindo; Charles S Dela Cruz; Carlos J Orihuela; Marcos I Restrepo Journal: Cytokine Date: 2016-10-01 Impact factor: 3.861