INTRODUCTION: The use of liver allografts from elderly donors (≥70 years) has increased because of organ shortage and increased life expectancy. The aim of this study is to evaluate the current utilization of elderly donors in United States, recipient selection, and their posttransplant outcomes. METHODS: A linkage between Scientific Registry of Transplant Recipients and University HealthSystem Consortium databases was performed. Between January 2007 and December 2011, 12,445 liver transplant (LT) recipients were identified and divided into 2 cohorts based on donor age: 70 years or older (n = 540) and younger than 60 years (n = 10,473). RESULTS: Elderly donors accounted for 4.3% of all donors used in the 5-year period. When compared to younger donors, elderly donors were more likely to be women, shared regionally or nationally, and used at higher volume centers. Elderly donor allografts were less likely to be used in recipients with model of end-stage liver disease score higher than 27 (13.2% vs. 23.0%, P < 0.001), hospitalized (16.8% vs. 21.7%, P = 0.03), or on hemodialysis at time of transplant (2.6% vs. 8.2%, P < 0.001). Both recipient groups had similar perioperative mortality, 30-day readmission rates, and short-term patient survival. In the multivariate analysis, including recipient, donor, center and regional factors, donor age 70 years or older was associated with slightly increased risk of graft loss (hazard ratio, 1.3; 95% confidence interval, 1.08-1.56; P = 0.005). CONCLUSIONS: The current trend toward the use of elderly donors in liver transplant recipients with low model of end-stage liver disease scores (<27), without hepatitis C, not hospitalized and not on dialysis, is associated with acceptable perioperative outcomes, patient survival, and slightly worse graft survival.
INTRODUCTION: The use of liver allografts from elderly donors (≥70 years) has increased because of organ shortage and increased life expectancy. The aim of this study is to evaluate the current utilization of elderly donors in United States, recipient selection, and their posttransplant outcomes. METHODS: A linkage between Scientific Registry of Transplant Recipients and University HealthSystem Consortium databases was performed. Between January 2007 and December 2011, 12,445 liver transplant (LT) recipients were identified and divided into 2 cohorts based on donor age: 70 years or older (n = 540) and younger than 60 years (n = 10,473). RESULTS: Elderly donors accounted for 4.3% of all donors used in the 5-year period. When compared to younger donors, elderly donors were more likely to be women, shared regionally or nationally, and used at higher volume centers. Elderly donor allografts were less likely to be used in recipients with model of end-stage liver disease score higher than 27 (13.2% vs. 23.0%, P < 0.001), hospitalized (16.8% vs. 21.7%, P = 0.03), or on hemodialysis at time of transplant (2.6% vs. 8.2%, P < 0.001). Both recipient groups had similar perioperative mortality, 30-day readmission rates, and short-term patient survival. In the multivariate analysis, including recipient, donor, center and regional factors, donor age 70 years or older was associated with slightly increased risk of graft loss (hazard ratio, 1.3; 95% confidence interval, 1.08-1.56; P = 0.005). CONCLUSIONS: The current trend toward the use of elderly donors in liver transplant recipients with low model of end-stage liver disease scores (<27), without hepatitis C, not hospitalized and not on dialysis, is associated with acceptable perioperative outcomes, patient survival, and slightly worse graft survival.
Authors: Christine E Haugen; Alvin G Thomas; Jacqueline Garonzik-Wang; Allan B Massie; Dorry L Segev Journal: Transplantation Date: 2018-09 Impact factor: 4.939
Authors: Christine E Haugen; Courtenay M Holscher; Xun Luo; Mary Grace Bowring; Babak J Orandi; Alvin G Thomas; Jacqueline Garonzik-Wang; Allan B Massie; Benjamin Philosophe; Mara McAdams-DeMarco; Dorry L Segev Journal: JAMA Surg Date: 2019-05-01 Impact factor: 14.766
Authors: Nicholas Gilbo; Ina Jochmans; Mauricio Sainz-Barriga; Frederik Nevens; Schalk van der Merwe; Wim Laleman; Chris Verslype; David Cassiman; Len Verbeke; Hannah van Malenstein; Tania Roskams; Jacques Pirenne; Diethard Monbaliu Journal: Transplant Direct Date: 2019-03-26
Authors: Vladimir J Lozanovski; Larissa T B Kerr; Elias Khajeh; Omid Ghamarnejad; Jan Pfeiffenberger; Katrin Hoffmann; De-Hua Chang; Markus Mieth; Thomas Longerich; Oliver Strobel; Karl Heinz Weiss; Markus W Büchler; Arianeb Mehrabi Journal: J Clin Med Date: 2019-10-15 Impact factor: 4.241