Anti-inflammatory studies on Euphorbia prostrata.

Anti-inflammatory studies were conducted in rats on an ethanol extract of whole plant Euphorbia prostrata and its partitioned fractions. The ethyl acetate fraction in an oral dose of 200 mg/kg, inhibited 76% of acute carrageenan-induced paw edema. A fraction, labelled as KSE-23, isolated from the ethyl acetate fraction inhibited 57% of pedal edema at a dose of 8 mg/kg. Acute inflammatory studies of fractions using histamine and bradykinin-induced pedal edema indicated a selective inhibition of histamine-induced edema, suggesting suppression of the first phase of the acute inflammatory reaction.