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Literature DB >> 26154054

Motivation to Eat-AgRP Neurons and Homeostatic Need.

Dengbao Yang¹, Tiemin Liu¹, Kevin W Williams².

Abstract

Activation of AgRP neurons potently induces feeding behaviors; however, whether this activity is involved in motivations of feeding behavior is unclear. A recent study in Nature (Betley et al., 2015) reports that AgRP neuron activity conditions learned behavior by transmitting a negative-valence signal: linking AgRP neurons to the preference of environmental cues associated with homeostatic need.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2015 PMID： 26154054 PMCID： PMC5528140 DOI： 10.1016/j.cmet.2015.06.018

Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287

10 in total

Review 1. Neural control of energy balance: translating circuits to therapies.

Authors: Laurent Gautron; Joel K Elmquist; Kevin W Williams
Journal: Cell Date: 2015-03-26 Impact factor: 41.582

2. Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein neurons.

Authors: Kanji A Takahashi; Roger D Cone
Journal: Endocrinology Date: 2004-12-09 Impact factor: 4.736

3. MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus.

Authors: Bhavik P Shah; Linh Vong; David P Olson; Shuichi Koda; Michael J Krashes; Chianping Ye; Zongfang Yang; Patrick M Fuller; Joel K Elmquist; Bradford B Lowell
Journal: Proc Natl Acad Sci U S A Date: 2014-08-25 Impact factor: 11.205

1 in total

Review 1. Melanocortin neurons: Multiple routes to regulation of metabolism.

Authors: Wen-Jie Shen; Ting Yao; Xingxing Kong; Kevin W Williams; Tiemin Liu
Journal: Biochim Biophys Acta Mol Basis Dis Date: 2017-05-09 Impact factor: 5.187

1 in total

Motivation to Eat-AgRP Neurons and Homeostatic Need.

Review 1. Neural control of energy balance: translating circuits to therapies.

2. Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein neurons.

3. MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus.

4. Rapid, reversible activation of AgRP neurons drives feeding behavior in mice.

Review 5. Central nervous system control of food intake and body weight.

6. Sensory detection of food rapidly modulates arcuate feeding circuits.

Review 7. GABAergic signaling by AgRP neurons prevents anorexia via a melanocortin-independent mechanism.

8. Parallel, redundant circuit organization for homeostatic control of feeding behavior.

9. AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training.

10. Neurons for hunger and thirst transmit a negative-valence teaching signal.

Review 1. Melanocortin neurons: Multiple routes to regulation of metabolism.