Literature DB >> 26150301

Phosphoinositide signaling in cancer: INPP4B Akt(s) out.

John F Woolley1, Irakli Dzneladze2, Leonardo Salmena3.   

Abstract

INPP4B acts as a tumor suppressor in various epithelial cancers by inhibiting PI3K/Akt signaling. Unexpectedly, tumor-promoting features of INPP4B in leukemia and breast cancer have been recently uncovered. In this spotlight, we discuss the seemingly paradoxical nature of INPP4B-mediated signaling in cancer.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Akt; INPP4B; PI3K; oncogene; phosphoinositide; tumor suppressor

Mesh：

Substances：

Year:  2015        PMID： 26150301     DOI： 10.1016/j.molmed.2015.06.006

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  10 in total

1.  INPP4B-mediated DNA repair pathway confers resistance to chemotherapy in acute myeloid leukemia.

Authors:  Ping Wang; Dan Ma; Jishi Wang; Qin Fang; Rui Gao; Weibing Wu; Lu Cao; Xiuying Hu; Jiangyuan Zhao; Yan Li
Journal:  Tumour Biol       Date:  2016-06-24

Review 2.  Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic.

Authors:  Andrea L Marat; Volker Haucke
Journal:  EMBO J       Date:  2016-02-17       Impact factor: 11.598

Review 3.  Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways.

Authors:  Johan-Owen De Craene; Dimitri L Bertazzi; Séverine Bär; Sylvie Friant
Journal:  Int J Mol Sci       Date:  2017-03-15       Impact factor: 5.923

4.  INPP4B restrains cell proliferation and metastasis via regulation of the PI3K/AKT/SGK pathway.

Authors:  Ying Chen; Zeyu Sun; Mei Qi; Xiao Wang; Weifang Zhang; Chunyan Chen; Juan Liu; Weiming Zhao
Journal:  J Cell Mol Med       Date:  2018-03-07       Impact factor: 5.310

5.  The impact of PI3K inhibitors on breast cancer cell and its tumor microenvironment.

Authors:  Hanjiao Qin; Linlin Liu; Shu Sun; Dan Zhang; Jiyao Sheng; Bingjin Li; Wei Yang
Journal:  PeerJ       Date:  2018-06-19       Impact factor: 2.984

6.  Investigating the duality of Inpp4b function in the cellular transformation of mouse fibroblasts.

Authors:  Emily Marie Mangialardi; Keyue Chen; Brittany Salmon; Jean Vacher; Leonardo Salmena
Journal:  Oncotarget       Date:  2019-10-29

7.  Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor in Multiple Myeloma.

Authors:  Yafei Wang; Lin Chen; Qian Li; Shuang Gao; Su Liu; Jing Ma; Ying Xie; Jingya Wang; Zeng Cao; Zhiqiang Liu
Journal:  Front Oncol       Date:  2022-01-05       Impact factor: 6.244

8.  INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia.

Authors:  Hongjun Jin; Liyuan Yang; Lu Wang; Zailin Yang; Qian Zhan; Yao Tao; Qin Zou; Yuting Tang; Jingrong Xian; Shuaishuai Zhang; Yipei Jing; Ling Zhang
Journal:  J Exp Clin Cancer Res       Date:  2018-01-17

9.  SubID, a non-median dichotomization tool for heterogeneous populations, reveals the pan-cancer significance of INPP4B and its regulation by EVI1 in AML.

Authors:  Irakli Dzneladze; John F Woolley; Carla Rossell; Youqi Han; Ayesha Rashid; Michael Jain; Jüri Reimand; Mark D Minden; Leonardo Salmena
Journal:  PLoS One       Date:  2018-02-07       Impact factor: 3.240

10.  Complex polymorphisms in endocytosis genes suggest alpha-cyclodextrin as a treatment for breast cancer.

Authors:  Knut M Wittkowski; Christina Dadurian; Martin P Seybold; Han Sang Kim; Ayuko Hoshino; David Lyden
Journal:  PLoS One       Date:  2018-07-02       Impact factor: 3.240
  10 in total

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