| Literature DB >> 26149757 |
Li-Wen Tian1, Yunjiang Feng1, Trong D Tran1, Yoko Shimizu2, Tom Pfeifer2, Paul I Forster3, Ronald J Quinn1.
Abstract
Mass-directed isolation of the CH2Cl2/MeOH extract from the bark of an Australian plant, Macropteranthes leichhardtii, resulted in the purification of a new phenylpropanoid glucoside, macropteranthol (1), together with four known analogues (2-5). The structure of compound 1 was elucidated by NMR and MS data analyses and quantum chemical calculations. Compounds 3 and 5 showed inhibitory activity against tyrosyl-DNA phosphodiesterase I with IC50 values of ∼1.0 μM.Entities:
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Year: 2015 PMID： 26149757 DOI： 10.1021/acs.jnatprod.5b00211
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050