| Literature DB >> 26147760 |
Mark J W Hanssen1, Joris Hoeks1, Boudewijn Brans2, Anouk A J J van der Lans1, Gert Schaart3, José J van den Driessche1, Johanna A Jörgensen1, Mark V Boekschoten4, Matthijs K C Hesselink3, Bas Havekes5, Sander Kersten4, Felix M Mottaghy6, Wouter D van Marken Lichtenbelt1, Patrick Schrauwen1.
Abstract
Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 °C) increased peripheral insulin sensitivity by ∼43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.Entities:
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Year: 2015 PMID： 26147760 DOI： 10.1038/nm.3891
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440