| Literature DB >> 26147686 |
Nguyet-Thin Luu1, Jennifer A Walker2, Cécile Bénézech1, Andrei A Kruglov3,4,5, Yunhua Loo6, Kyoko Nakamura1, Yang Zhang1, Saba Nayar1, Lucy H Jones7, Adriana Flores-Langarica1, Alistair McIntosh1, Jennifer Marshall1, Francesca Barone1, Gurdyal Besra8, Katherine Miles9, Judith E Allen7, Mohini Gray9, George Kollias10, Adam F Cunningham1, David R Withers1, Kai Michael Toellner1, Nick D Jones1, Marc Veldhoen6, Sergei A Nedospasov3,4,5, Andrew N J McKenzie2, Jorge H Caamaño1.
Abstract
Fat-associated lymphoid clusters (FALCs) are a type of lymphoid tissue associated with visceral fat. Here we found that the distribution of FALCs was heterogeneous, with the pericardium containing large numbers of these clusters. FALCs contributed to the retention of B-1 cells in the peritoneal cavity through high expression of the chemokine CXCL13, and they supported B cell proliferation and germinal center differentiation during peritoneal immunological challenges. FALC formation was induced by inflammation, which triggered the recruitment of myeloid cells that expressed tumor-necrosis factor (TNF) necessary for signaling via the TNF receptors in stromal cells. Natural killer T cells (NKT cells) restricted by the antigen-presenting molecule CD1d were likewise required for the inducible formation of FALCs. Thus, FALCs supported and coordinated the activation of innate B cells and T cells during serosal immune responses.Entities:
Mesh：
Substances：
Year: 2015 PMID： 26147686 PMCID： PMC4512620 DOI： 10.1038/ni.3215
Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 25.606