Li Li1, Rachel A Chassan1, Emily H Bruer1, Barbara A Gower2, Richard C Shelton1. 1. Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, USA. 2. Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Abstract
OBJECTIVE: The reports regarding the associations between childhood maltreatment (CM) and body fat composition remain heterogeneous in humans although they are indicated in preclinical studies. In addition, the effects of CM subtypes on different types of body fat are unclear. Thus, in this study, the associations between CM and its subtypes with body fat were determined and the potential pathways were explored. METHODS: The participants were assessed for a history of CM by the Childhood Trauma Questionnaire and were divided into the CM group (with CM exposures) and non-CM group (without CM exposures). Body composition was measured by dual-energy X-ray absorptiometry. Salivary and blood samples were provided by the subjects. RESULTS: Compared with the non-CM group, subjects with a history of CM had greater visceral fat mass (1,136 ± 160 vs. 836 ± 116 g, P < 0.05) but not total body fat, android fat, body mass index, or waist-to-hip ratio. In addition, subjects with CM had a blunted cortisol awakening response and elevated inflammatory factors. Correlation analysis indicated that CM subtypes had differential effects on visceral adiposity and cortisol awakening response. CONCLUSIONS: It is suggested by our results that CM exposure is linked with increased visceral fat deposition, and the perturbation of the hypothalamic-pituitary-adrenal axis activity and activation of the immune system may be two potential pathways through which this relationship is explained.
OBJECTIVE: The reports regarding the associations between childhood maltreatment (CM) and body fat composition remain heterogeneous in humans although they are indicated in preclinical studies. In addition, the effects of CM subtypes on different types of body fat are unclear. Thus, in this study, the associations between CM and its subtypes with body fat were determined and the potential pathways were explored. METHODS: The participants were assessed for a history of CM by the Childhood Trauma Questionnaire and were divided into the CM group (with CM exposures) and non-CM group (without CM exposures). Body composition was measured by dual-energy X-ray absorptiometry. Salivary and blood samples were provided by the subjects. RESULTS: Compared with the non-CM group, subjects with a history of CM had greater visceral fat mass (1,136 ± 160 vs. 836 ± 116 g, P < 0.05) but not total body fat, android fat, body mass index, or waist-to-hip ratio. In addition, subjects with CM had a blunted cortisol awakening response and elevated inflammatory factors. Correlation analysis indicated that CM subtypes had differential effects on visceral adiposity and cortisol awakening response. CONCLUSIONS: It is suggested by our results that CM exposure is linked with increased visceral fat deposition, and the perturbation of the hypothalamic-pituitary-adrenal axis activity and activation of the immune system may be two potential pathways through which this relationship is explained.
Authors: Mary F Dallman; Susan F Akana; Kevin D Laugero; Francisca Gomez; Sotara Manalo; M E Bell; Seema Bhatnagar Journal: Physiol Behav Date: 2003-06
Authors: D P Bernstein; L Fink; L Handelsman; J Foote; M Lovejoy; K Wenzel; E Sapareto; J Ruggiero Journal: Am J Psychiatry Date: 1994-08 Impact factor: 18.112
Authors: Audrey R Tyrka; Lauren M Wier; Lawrence H Price; Kobita Rikhye; Nicole S Ross; George M Anderson; Charles W Wilkinson; Linda L Carpenter Journal: Horm Behav Date: 2008-02-21 Impact factor: 3.587
Authors: Ian C G Weaver; Nadia Cervoni; Frances A Champagne; Ana C D'Alessio; Shakti Sharma; Jonathan R Seckl; Sergiy Dymov; Moshe Szyf; Michael J Meaney Journal: Nat Neurosci Date: 2004-06-27 Impact factor: 24.884
Authors: Charlotte O Ladd; Rebecca L Huot; K V Thrivikraman; Charles B Nemeroff; Paul M Plotsky Journal: Biol Psychiatry Date: 2004-02-15 Impact factor: 13.382
Authors: I M O'Shaughnessy; T J Myers; K Stepniakowski; P Nazzaro; T M Kelly; R G Hoffmann; B M Egan; A H Kissebah Journal: Hypertension Date: 1995-07 Impact factor: 10.190
Authors: Katie A Ports; Dawn M Holman; Angie S Guinn; Sanjana Pampati; Karen E Dyer; Melissa T Merrick; Natasha Buchanan Lunsford; Marilyn Metzler Journal: J Pediatr Nurs Date: 2018-11-07 Impact factor: 2.145
Authors: Molly Orcutt; Wendy C King; Melissa A Kalarchian; Michael J Devlin; Marsha D Marcus; Luis Garcia; Kristine J Steffen; James E Mitchell Journal: Surg Obes Relat Dis Date: 2018-11-15 Impact factor: 4.734
Authors: Rebecca L Emery Tavernier; Susan M Mason; Rona L Levy; Elisabeth M Seburg; Nancy E Sherwood Journal: Obesity (Silver Spring) Date: 2022-01 Impact factor: 5.002
Authors: Natalie G Keirns; Bryant H Keirns; Cindy E Tsotsoros; Christina M Sciarrillo; Sam R Emerson; Misty A W Hawkins Journal: Stigma Health Date: 2022-05
Authors: Francisco D Marquez; Patricia M Risica; Karen Jennings Mathis; Adam Sullivan; Asi Polly Gobin; Audrey R Tyrka Journal: Appetite Date: 2021-03-06 Impact factor: 5.016
Authors: Ana Luiza G Soares; Alicia Matijasevich; Ana M B Menezes; Maria Cecília Assunção; Fernando C Wehrmeister; Laura D Howe; Helen Gonçalves Journal: Obesity (Silver Spring) Date: 2017-11-14 Impact factor: 5.002