Literature DB >> 26146471

PHOTOLABILE A1-ADENOSINE RECEPTOR AGONISTS AS "CAGED" ELECTROPHYSIOLOGICAL PROBES.

Michel C Maillard1, Lauren Arlinghaus2, Marc Glashofer1, Kevin S Lee2, Kenneth A Jacobson1.   

Abstract

5'-Ether derivatives of the potent adenosine agonist N6-cyclopentyladenosine (CPA) were designed as "caged" ligands for the activation of A1-adenosine receptors following in situ photolysis. The synthesis involved a 2',3'-diol protection scheme using the acid labile ethoxymethynyl group. Generation of CPA was demonstrated chromatographically and in a bioassay measuring the inhibition of synaptic potentials in the rat hippocampus.

Entities:  

Year:  1991        PMID： 26146471      PMCID： PMC4489149     

Source DB:  PubMed          Journal:  Med Chem Res        ISSN： 1054-2523            Impact factor:   1.965


  13 in total

1.  Adenosine receptor subtypes in the brainstem mediate distinct cardiovascular response patterns.

Authors:  R A Barraco; M R el-Ridi; E Ergene; J W Phillis
Journal:  Brain Res Bull       Date:  1991-01       Impact factor: 4.077

Review 2.  The cardiac effects of adenosine.

Authors:  L Belardinelli; J Linden; R M Berne
Journal:  Prog Cardiovasc Dis       Date:  1989 Jul-Aug       Impact factor: 8.194

3.  A1 and A2 adenosine receptor activation inhibits and stimulates renin secretion of rat renal cortical slices.

Authors:  P C Churchill; M C Churchill
Journal:  J Pharmacol Exp Ther       Date:  1985-03       Impact factor: 4.030

4.  N6-cycloalkyladenosines. Potent, A1-selective adenosine agonists.

Authors:  W H Moos; D S Szotek; R F Bruns
Journal:  J Med Chem       Date:  1985-10       Impact factor: 7.446

5.  An A1-adenosine receptor, characterized by [3H] cyclohexyladenosine binding, mediates the depression of evoked potentials in a rat hippocampal slice preparation.

Authors:  M Reddington; K S Lee; P Schubert
Journal:  Neurosci Lett       Date:  1982-03-05       Impact factor: 3.046

6.  N6-substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptors.

Authors:  R A Olsson; S Kusachi; R D Thompson; D Ukena; W Padgett; J W Daly
Journal:  J Med Chem       Date:  1986-09       Impact factor: 7.446

7.  2-(Arylalkylamino)adenosin-5'-uronamides: a new class of highly selective adenosine A2 receptor ligands.

Authors:  A J Hutchison; M Williams; R de Jesus; R Yokoyama; H H Oei; G R Ghai; R L Webb; H C Zoganas; G A Stone; M F Jarvis
Journal:  J Med Chem       Date:  1990-07       Impact factor: 7.446

8.  The anticonvulsive action of adenosine: a postsynaptic, dendritic action by a possible endogenous anticonvulsant.

Authors:  K S Lee; P Schubert; U Heinemann
Journal:  Brain Res       Date:  1984-10-29       Impact factor: 3.252

9.  Electrophysiological responses to adenosine analogs in rat hippocampus and cerebellum: evidence for mediation by adenosine receptors of the A1 subtype.

Authors:  T V Dunwiddie; A S Basile; M R Palmer
Journal:  Life Sci       Date:  1984-01-02       Impact factor: 5.037

10.  Functionalized congeners of adenosine: preparation of analogues with high affinity for A1-adenosine receptors.

Authors:  K A Jacobson; K L Kirk; W L Padgett; J W Daly
Journal:  J Med Chem       Date:  1985-09       Impact factor: 7.446
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.