Literature DB >> 2614419

Spectroscopic and biological investigation of nimbolide and 28-deoxonimbolide from Azadirachta indica.

P G Kigodi1, G Blaskó, Y Thebtaranonth, J M Pezzuto, G A Cordell.   

Abstract

The reisolation of nimbolide [1] from Azadirachta indica of Tanzanian origin and the isolation and structure elucidation of a new limonoid, 28-deoxonimbolide [2], from the same plant source are reported. For the first time, unambiguous 1H- and 13C-nmr assignments of compounds 1 and 2 are presented, as well as their in vitro cytotoxic activity against human tumor cell lines.

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Year:  1989        PMID: 2614419     DOI: 10.1021/np50066a008

Source DB:  PubMed          Journal:  J Nat Prod        ISSN: 0163-3864            Impact factor:   4.050


  13 in total

1.  Modulatory effects of Azadirachta indica on benzo(a)pyrene-induced forestomach tumorigenesis in mice.

Authors:  Subhash Chander Gangar; Rajat Sandhir; Durg Vijay Rai; Ashwani Koul
Journal:  World J Gastroenterol       Date:  2006-05-07       Impact factor: 5.742

2.  Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents.

Authors:  Subash C Gupta; Sahdeo Prasad; Simone Reuter; Ramaswamy Kannappan; Vivek R Yadav; Jayaraj Ravindran; Padmanabhan S Hema; Madan M Chaturvedi; Mangalam Nair; Bharat B Aggarwal
Journal:  J Biol Chem       Date:  2010-09-09       Impact factor: 5.157

3.  Inhibition of cell survival and proliferation by nimbolide in human androgen-independent prostate cancer (PC-3) cells: involvement of the PI3K/Akt pathway.

Authors:  Paulraj Raja Singh; Elayapillai Sugantha Priya; Solaimuthu Balakrishnan; Ramachandran Arunkumar; Govindaraj Sharmila; Manikkam Rajalakshmi; Jagadeesan Arunakaran
Journal:  Mol Cell Biochem       Date:  2016-12-26       Impact factor: 3.396

4.  The neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis.

Authors:  G Harish Kumar; R Vidya Priyadarsini; G Vinothini; P Vidjaya Letchoumy; S Nagini
Journal:  Invest New Drugs       Date:  2009-05-21       Impact factor: 3.850

5.  Nimbolide, a limonoid triterpene, inhibits growth of human colorectal cancer xenografts by suppressing the proinflammatory microenvironment.

Authors:  Subash C Gupta; Sahdeo Prasad; Dhanya R Sethumadhavan; Mangalam S Nair; Yin-Yuan Mo; Bharat B Aggarwal
Journal:  Clin Cancer Res       Date:  2013-06-13       Impact factor: 12.531

6.  Nimbolide a limonoid from Azadirachta indica inhibits proliferation and induces apoptosis of human choriocarcinoma (BeWo) cells.

Authors:  G Harish Kumar; K V P Chandra Mohan; A Jagannadha Rao; S Nagini
Journal:  Invest New Drugs       Date:  2008-08-22       Impact factor: 3.850

7.  Nimbolide reduces CD44 positive cell population and induces mitochondrial apoptosis in pancreatic cancer cells.

Authors:  Sandeep Kumar; Joseph R Inigo; Rahul Kumar; Ajay K Chaudhary; Jordan O'Malley; Srimmitha Balachandar; Jianmin Wang; Kristopher Attwood; Neelu Yadav; Steven Hochwald; Xinjiang Wang; Dhyan Chandra
Journal:  Cancer Lett       Date:  2017-10-26       Impact factor: 8.679

8.  Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.

Authors:  Yulin Ren; A Douglas Kinghorn
Journal:  J Med Chem       Date:  2020-12-08       Impact factor: 7.446

Review 9.  Review on molecular and chemopreventive potential of nimbolide in cancer.

Authors:  Perumal Elumalai; Jagadeesan Arunakaran
Journal:  Genomics Inform       Date:  2014-12-31

Review 10.  Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development.

Authors:  Lingzhi Wang; Do Dang Khoa Phan; Jingwen Zhang; Pei-Shi Ong; Win Lwin Thuya; Ross Soo; Andrea Li-Ann Wong; Wei Peng Yong; Soo Chin Lee; Paul Chi-Lui Ho; Gautam Sethi; Boon Cher Goh
Journal:  Oncotarget       Date:  2016-07-12
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