Literature DB >> 26143582

An international effort to cure a global health problem: A report on the 19th Hemoglobin Switching Conference.

Gerd A Blobel1, David Bodine2, Marjorie Brand3, John Crispino4, Marella F T R de Bruijn5, David Nathan6, Thalia Papayannopoulou7, Catherine Porcher5, John Strouboulis8, Len Zon9, Douglas R Higgs5, George Stamatoyannopoulos7, James Douglas Engel10.   

Abstract

Every 2 years since 1978, an international group of scientists, physicians, and other researchers meet to discuss the latest developments in the underlying etiology, mechanisms of action, and developmental acquisition of cellular and systemic defects exhibited and elicited by the most common inherited human disorders, the hemoglobinopathies. The 19th Hemoglobin Switching Conference, held in September 2014 at St. John's College in Oxford, once again exceeded all expectations by describing cutting edge research in cellular, molecular, developmental, and genomic advances focused on these diseases. The conference comprised about 60 short talks over 3 days by leading investigators in the field. This meeting report describes the highlights of the conference.
Copyright © 2015 ISEH - International Society for Experimental Hematology. All rights reserved.

Entities:  

Mesh:

Substances:

Year:  2015        PMID: 26143582      PMCID: PMC5490074          DOI: 10.1016/j.exphem.2015.06.008

Source DB:  PubMed          Journal:  Exp Hematol        ISSN: 0301-472X            Impact factor:   3.084


  73 in total

1.  Distinct origins of adult and embryonic blood in Xenopus.

Authors:  A Ciau-Uitz; M Walmsley; R Patient
Journal:  Cell       Date:  2000-09-15       Impact factor: 41.582

2.  Looping and interaction between hypersensitive sites in the active beta-globin locus.

Authors:  Bas Tolhuis; Robert Jan Palstra; Erik Splinter; Frank Grosveld; Wouter de Laat
Journal:  Mol Cell       Date:  2002-12       Impact factor: 17.970

3.  Identification of genetic elements that autonomously determine DNA methylation states.

Authors:  Florian Lienert; Christiane Wirbelauer; Indrani Som; Ann Dean; Fabio Mohn; Dirk Schübeler
Journal:  Nat Genet       Date:  2011-10-02       Impact factor: 38.330

4.  Developmental regulation of beta-globin gene switching.

Authors:  O R Choi; J D Engel
Journal:  Cell       Date:  1988-10-07       Impact factor: 41.582

5.  c-myb supports erythropoiesis through the transactivation of KLF1 and LMO2 expression.

Authors:  Elisa Bianchi; Roberta Zini; Simona Salati; Elena Tenedini; Ruggiero Norfo; Enrico Tagliafico; Rossella Manfredini; Sergio Ferrari
Journal:  Blood       Date:  2010-08-04       Impact factor: 22.113

6.  Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia.

Authors:  Marina Cavazzana-Calvo; Emmanuel Payen; Olivier Negre; Gary Wang; Kathleen Hehir; Floriane Fusil; Julian Down; Maria Denaro; Troy Brady; Karen Westerman; Resy Cavallesco; Beatrix Gillet-Legrand; Laure Caccavelli; Riccardo Sgarra; Leila Maouche-Chrétien; Françoise Bernaudin; Robert Girot; Ronald Dorazio; Geert-Jan Mulder; Axel Polack; Arthur Bank; Jean Soulier; Jérôme Larghero; Nabil Kabbara; Bruno Dalle; Bernard Gourmel; Gérard Socie; Stany Chrétien; Nathalie Cartier; Patrick Aubourg; Alain Fischer; Kenneth Cornetta; Frédéric Galacteros; Yves Beuzard; Eliane Gluckman; Frederick Bushman; Salima Hacein-Bey-Abina; Philippe Leboulch
Journal:  Nature       Date:  2010-09-16       Impact factor: 49.962

7.  The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle cell syndromes: results of a 17-year, single-center trial (LaSHS).

Authors:  Ersi Voskaridou; Dimitrios Christoulas; Antonios Bilalis; Eleni Plata; Konstantinos Varvagiannis; George Stamatopoulos; Klio Sinopoulou; Aggeliki Balassopoulou; Dimitris Loukopoulos; Evangelos Terpos
Journal:  Blood       Date:  2009-11-10       Impact factor: 22.113

8.  Simvastatin and t-butylhydroquinone suppress KLF1 and BCL11A gene expression and additively increase fetal hemoglobin in primary human erythroid cells.

Authors:  Elizabeth R Macari; Emily K Schaeffer; Rachel J West; Christopher H Lowrey
Journal:  Blood       Date:  2012-12-06       Impact factor: 22.113

9.  Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A.

Authors:  Jian Xu; Daniel E Bauer; Marc A Kerenyi; Thuy D Vo; Serena Hou; Yu-Jung Hsu; Huilan Yao; Jennifer J Trowbridge; Gail Mandel; Stuart H Orkin
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-01       Impact factor: 11.205

10.  Mutations in Kruppel-like factor 1 cause transfusion-dependent hemolytic anemia and persistence of embryonic globin gene expression.

Authors:  Vip Viprakasit; Supachai Ekwattanakit; Suchada Riolueang; Nipon Chalaow; Chris Fisher; Karen Lower; Hitoshi Kanno; Kalaya Tachavanich; Sasithorn Bejrachandra; Jariya Saipin; Monthana Juntharaniyom; Kleebsabai Sanpakit; Voravarn S Tanphaichitr; Duantida Songdej; Christian Babbs; Richard J Gibbons; Sjaak Philipsen; Douglas R Higgs
Journal:  Blood       Date:  2014-01-17       Impact factor: 22.113

View more
  5 in total

Review 1.  Fetal hemoglobin in sickle cell anemia.

Authors:  Martin H Steinberg
Journal:  Blood       Date:  2020-11-19       Impact factor: 22.113

Review 2.  Evolving treatment paradigms in sickle cell disease.

Authors:  Ramasamy Jagadeeswaran; Angela Rivers
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2017-12-08

Review 3.  HbE/β-Thalassemia and Oxidative Stress: The Key to Pathophysiological Mechanisms and Novel Therapeutics.

Authors:  Rhoda Elison Hirsch; Nathawut Sibmooh; Suthat Fucharoen; Joel M Friedman
Journal:  Antioxid Redox Signal       Date:  2016-11-28       Impact factor: 8.401

Review 4.  Potential new approaches to the management of the Hb Bart's hydrops fetalis syndrome: the most severe form of α-thalassemia.

Authors:  Andrew J King; Douglas R Higgs
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2018-11-30

5.  Reactivation of a developmentally silenced embryonic globin gene.

Authors:  Andrew J King; Duantida Songdej; Damien J Downes; Robert A Beagrie; Siyu Liu; Megan Buckley; Peng Hua; Maria C Suciu; A Marieke Oudelaar; Lars L P Hanssen; Danuta Jeziorska; Nigel Roberts; Stephanie J Carpenter; Helena Francis; Jelena Telenius; Aude-Anais Olijnik; Jacqueline A Sharpe; Jacqueline Sloane-Stanley; Jennifer Eglinton; Mira T Kassouf; Stuart H Orkin; Len A Pennacchio; James O J Davies; Jim R Hughes; Douglas R Higgs; Christian Babbs
Journal:  Nat Commun       Date:  2021-07-21       Impact factor: 14.919

  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.