Isabelle E Bauer1, Gabriele Jordan2, Jair C Soares1, Thomas D Meyer3. 1. University of Texas Health Science Center at Houston, Department of Psychiatry and Behavioral Sciences, 77054 Houston, TX, USA. 2. Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK. 3. University of Texas Health Science Center at Houston, Department of Psychiatry and Behavioral Sciences, 77054 Houston, TX, USA; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK. Electronic address: thomas.d.meyer@uth.tmc.edu.
Abstract
OBJECTIVE: Bipolar disorder (BD) is characterized by cognitive deficits. Usually individuals at risk for BD do not exhibit such deficits but they might be evident under cognitive or emotionally stressful conditions. To our knowledge this is the first study examining working memory capacity under mood induction in individuals at risk for BD. METHODS: Using the Hypomanic Personality Scale (HPS) 68 participants out of an initial pool of 148 students were divided into groups at high and low risk for BD. They completed twice a Dual Task Paradigm (DTP) task assessed under high and low cognitive load prior to and following a negative mood induction. RESULTS: As expected stimuli incongruency, high cognitive load and mood induction increased response times. Contrary to our hypothesis the mood induction did not differentially affect at-risk individuals. However, they generally reacted faster to neutral stimuli compared to those at low risk. CONCLUSIONS: While we replicated former results related to the DTP, we did not find evidence for the hypothesis that individuals putatively at risk for BD will be more affected by negative mood when doing such a cognitive task. Replication using a larger sample is needed which should also examine whether changes in positive mood might more relevant in the context of risk for mania.
OBJECTIVE:Bipolar disorder (BD) is characterized by cognitive deficits. Usually individuals at risk for BD do not exhibit such deficits but they might be evident under cognitive or emotionally stressful conditions. To our knowledge this is the first study examining working memory capacity under mood induction in individuals at risk for BD. METHODS: Using the Hypomanic Personality Scale (HPS) 68 participants out of an initial pool of 148 students were divided into groups at high and low risk for BD. They completed twice a Dual Task Paradigm (DTP) task assessed under high and low cognitive load prior to and following a negative mood induction. RESULTS: As expected stimuli incongruency, high cognitive load and mood induction increased response times. Contrary to our hypothesis the mood induction did not differentially affect at-risk individuals. However, they generally reacted faster to neutral stimuli compared to those at low risk. CONCLUSIONS: While we replicated former results related to the DTP, we did not find evidence for the hypothesis that individuals putatively at risk for BD will be more affected by negative mood when doing such a cognitive task. Replication using a larger sample is needed which should also examine whether changes in positive mood might more relevant in the context of risk for mania.
Authors: Isabelle E Bauer; Thomas W Frazier; Thomas D Meyer; Eric Youngstrom; Giovana B Zunta-Soares; Jair C Soares Journal: J Child Adolesc Psychopharmacol Date: 2015-10-15 Impact factor: 2.576