Literature DB >> 26142491

Primaquine-pyrimidine hybrids: synthesis and dual-stage antiplasmodial activity.

Hardeep Kaur1, Marta Machado2, Carmen de Kock3, Peter Smith3, Kelly Chibale4, Miguel Prudêncio2, Kamaljit Singh5.   

Abstract

A series of novel pyrimidine-primaquine hybrids were synthesized and their effectiveness against the blood and liver stages of malaria parasites was evaluated. The hybrids displayed enhanced liver stage in vitro activity against P. berghei liver stage infection.
Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Antiplasmodial agents; Blood stage activity; Hybrid drugs; Liver stage activity; Primaquine; Pyrimidine

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Year:  2015        PMID： 26142491     DOI： 10.1016/j.ejmech.2015.06.045

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  7 in total

Review 1.  Are Antimalarial Hybrid Molecules a Close Reality or a Distant Dream?

Authors:  Drishti Agarwal; Rinkoo D Gupta; Satish K Awasthi
Journal:  Antimicrob Agents Chemother       Date:  2017-04-24       Impact factor: 5.191

2.  One-pot synthesis, X-ray crystal structure, and identification of potential molecules against COVID-19 main protease through structure-guided modeling and simulation approach.

Authors:  Youness El Bakri; Malahat Musrat Kurbanova; Sabir Ali Siddique; Sajjad Ahmad; Souraya Goumri-Said
Journal:  Arab J Chem       Date:  2022-09-15       Impact factor: 6.212

Review 3.  Primaquine derivatives: Modifications of the terminal amino group.

Authors:  Branka Zorc; Ivana Perković; Kristina Pavić; Zrinka Rajić; Maja Beus
Journal:  Eur J Med Chem       Date:  2019-08-23       Impact factor: 6.514

4.  Novel Pyrimidine Derivatives as Potential Anticancer Agents: Synthesis, Biological Evaluation and Molecular Docking Study.

Authors:  Beata Tylińska; Benita Wiatrak; Żaneta Czyżnikowska; Aneta Cieśla-Niechwiadowicz; Elżbieta Gębarowska; Anna Janicka-Kłos
Journal:  Int J Mol Sci       Date:  2021-04-07       Impact factor: 5.923

5.  Synthesis and antiplasmodial activity of regioisomers and epimers of second-generation dual acting ivermectin hybrids.

Authors:  Lovepreet Singh; Diana Fontinha; Denise Francisco; Miguel Prudêncio; Kamaljit Singh
Journal:  Sci Rep       Date:  2022-01-12       Impact factor: 4.996

6.  Synthesis, crystal structure and antibacterial studies of dihydropyrimidines and their regioselectively oxidized products.

Authors:  Alakbar E Huseynzada; Christian Jelch; Haji Vahid N Akhundzada; Sarra Soudani; Cherif Ben Nasr; Aygun Israyilova; Filippo Doria; Ulviyya A Hasanova; Rana F Khankishiyeva; Mauro Freccero
Journal:  RSC Adv       Date:  2021-02-03       Impact factor: 3.361

7.  Novel Pyridothienopyrimidine Derivatives: Design, Synthesis and Biological Evaluation as Antimicrobial and Anticancer Agents.

Authors:  Eman M Mohi El-Deen; Manal M Anwar; Amina A Abd El-Gwaad; Eman A Karam; Mohamed K El-Ashrey; Rafika R Kassab
Journal:  Molecules       Date:  2022-01-26       Impact factor: 4.411
  7 in total

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